Disturbance of neural activity by sedative drugs has been proposed to trigger a homeostatic response that resists unfavorable changes in net cellular excitability, leading to tolerance and dependence. The Drosophila slo gene encodes a BK-type Ca(2+)-activated K(+) channel implicated in functional tolerance to alcohol and volatile anesthetics. We hypothesized that increased expression of BK chan...

AIMS To provide an overview of illicit weight-reducing agents found in over-the-counter slimming products ingested by poisoned patients. METHODS The clinical details and analytical findings of slimming products involved in poisoning cases between 2004 and 2009 were reviewed. RESULTS Sixty-six (including one fatal) poisoning cases were encountered. Eighty-one products were analysed and found...

Health communication is critical component of effective health delivery. While there are studies on the readability Patient Information Leaflets (PILs) around world, so far, only one Ghanaian study that explored language patient information leaflets for malaria. The present explores PILs seven common ailments in Ghana. In all, 68 were purposely sampled study. Using SMOG and Flesch Kincaid grade...

Neuroenhancement (NE) is the non-medical use of psychoactive substances to produce a subjective enhancement in psychological functioning and experience. So far empirical investigations of individuals' motivation for NE however have been hampered by the lack of theoretical foundation. This study aimed to apply drug instrumentalization theory to user motivation for NE. We argue that NE should be ...

Over-the-counter drugs are medications that are available without the requirement of a prescription. They are considered relatively safe and well-tolerated when taken in accordance with the dosing instructions on the package label. However, when taken alone or in combination with other drugs, they possess pharmacological properties that have the potential to facilitate sexual assault. This chap...

388 Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most widely used over-the-counter (OTC) drugs worldwide. Though the extent of their usage in the Indian population is not known, it is likely to be large. Their major usage is as casual prescription for their analgesic and anti-inflammatory action, and in organized rheumatology and orthopedic practice. These drugs have also been ...

In the article is presented the case of trust-based marketing of over-the-counter (OTC) medicines. The relationship between the hypotheses was tested by means of structural equation modelling. The results of the first model show that the predictor variable (consumer satisfaction with safety and information) has a significant effect on the mediator variable (consumer trust). The results of the s...