Bromodomains are α-helical bundles of approximately 110 residues that recognize acetylated lysine side chains mainly on histone tails. Bromodomains are known to play an important role in cancer and inflammation, and as such, significant efforts are being made to identify small-molecule inhibitors of these epigenetic reader proteins. Here, explicit solvent molecular dynamics (MD) simulations of ...

Poly (vinylpyrrolidone)-grafted silica as an organic-inorganic hybrid material was used as an effective heterogeneous polymeric cosolvent catalyst in organic reactions. This modified silica catalyzed nucleophilic displacement of alkyl halides for easy preparation of alkyl thiocyanates, alkyl cyanides, alkyl azides and alkyl aryl ethers. Furthermore, the catalyst was applied for the conversion o...

Urethan, a potent teratogenic and carcinogenic agent in experimental animals, has been used in Japan for the past 25 years as a cosolvent of water-insoluble analgesic and sedative drugs. Urethan is used also as a solubilizer and cosolvent for pesticides, fumigants, and cosmetics, because it is a good solvent for various organic materials (6). In the past, urethan was used clinically as an antin...