THiE problem of correcting the refractive error of an aphakic eye other than by prescribing the cumbersome cataract lenses still remains open, in spite of the excellent work done in this field by Ridley, and all its modifications. In search of a method which might combine greater safety for the patient with a simpler operative technique, an operation has been devised which consists in implantin...

BACKGROUND Repeat penetrating keratoplasty is quite often required as there is high chance of failure of the primary graft particularly in the developing world. We planned a study to analyze the indications and outcome of repeat penetrating keratoplasty in a tertiary care centre in India. METHODS A retrospective analysis of all the patients who underwent repeat penetrating keratoplasty, betwe...

OBJECTIVES To retrospectively evaluate the complications, graft clarity, and outcomes associated with the use of commercially available porcine urinary bladder submucosa (ACell Vet(™) ) alone for corneal reconstruction in dogs and cats. PROCEDURES Dogs or cats receiving an ACell Vet(™) graft for corneal reconstruction due to severe ulcerative keratitis or after a keratectomy to remove a corne...

PURPOSE The aim of this study was to describe the aims, methods, donor and recipient cohort characteristics, and potential impact of the Cornea Preservation Time Study (CPTS). METHODS The CPTS is a randomized clinical trial conducted at 40 clinical sites (70 surgeons) designed to assess the effect of donor cornea preservation time (PT) on graft survival 3 years after Descemet stripping automa...

PURPOSE Our aim was to determine the effect of a surgical technique on biomaterial implant performance, specifically graft retention. METHODS Twelve mini pigs were implanted with cell-free, 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC)/N-hydroxysuccinimide (NHS) cross-linked recombinant human collagen type III (RHCIII) hydrogels as substitutes for donor corneal allografts using overly...

AIMS The aim of this work was to investigate different surgical options for the repair of the ocular surface, using various extensions of the procedure of limbal stem cell allotransplantation. METHODS/RESULTS Straightforward lamellar limbal transplantation was performed in one patient with contact lens induced limbal stem cell failure. A second patient with a neoplastic corneal lesion underwe...

PURPOSE The purpose of our study is to develop a pre-clinical model of corneal graft rejection in the semi-inbred NIH minipig as a model of human rejection. METHODS NIH minipigs received corneal allografts with MHC and minor mismatches, or minor mismatches alone. Clinical rejection was monitored, and major subsets of leukocytes and ingress of vessels were quantified post-mortem by automated d...

OBJECTIVE To review the results of combined trabeculotomy and trabeculectomy as a primary procedure in congenital glaucoma. METHODS A retrospective review of 100 consecutive eyes in 60 children undergoing surgery from December 30, 1991, to April 17, 1996. Features at initial examination, ie, corneal size and clarity, presence or absence of anterior segment structural abnormalities, and intrao...

Chemical injuries of the eye may produce extensive damage to the ocular surface epithelium, cornea, and anterior segment, resulting in permanent unilateral or bilateral visual impairment. Pathophysiological events which may influence the final visual prognosis and which are amenable to therapeutic modulation include 1) ocular surface injury, repair, and differentiation, 2) corneal stromal matri...