PURPOSE To analyze in vivo corneal morphology and ultrastructural features in patients with classic Ehlers-Danlos syndrome (EDS). METHODS Fifty patients with classic EDS and 50 age- and sex-matched control subjects were studied. A clinical evaluation was made with the Ocular Surface Disease Index (OSDI) questionnaire and a complete ophthalmic examination, including assessment of the best-corr...

INTRODUCTION We describe a patient with corneal and scleral dellen, which occurred after an uneventful pterygium excision without adjunctive therapy and a subsequent febrile episode. CASE REPORT A 43-year-old woman presented with a history of recurrent irritation in her right eye and a diagnosis of pterygium. The pterygium was excised under local anesthesia with the bare scleral technique and...

BACKGROUND Anesthetic endpoints of unconsciousness and immobility result from agent effects on both brain and spinal cord that are difficult to separate during systemic administration. To investigate cerebral mechanism of anesthetic-induced unconsciousness, the authors studied behavioral and electrophysiologic effects of four anesthetics infused intracerebroventricularly to conscious rats. The ...

postoperative corneal sensitivity; however, no signifi­ cant changes were detected in the intergroup compar­ isons. (4) Group B had an 8.2% reduction in ECC, significantly higher than in the rest of the groups (Group A1: 4.8%; Group A2: 5.0%). (5) Endothelial cell loss showed linear correlation with CDE (Group B: r Z 0.47; Group A2: r Z 0.81; both P ! .01) (Figure 1). (6) Group A2 patients had ...

BACKGROUND The intraocular pressures and biomechanical parameters measured by the ocular response analyzer make the analyzer a useful tool for the diagnosis and management of anterior segment disease. This observational study was designed to investigate the effect of topical anesthesia on the parameters measured by the ocular response analyzer: corneal hysteresis, corneal resistance factor, Gol...

PURPOSE To investigate the effect of hinge width on corneal sensation and dry-eye syndrome after laser in situ keratomileusis (LASIK). SETTING TLC Laser Eye Center, Garden City, New York, USA. METHODS Fifty-four patients at least 18 years of age had bilateral LASIK with a narrow nasal hinge microkeratome flap in 1 eye and a wider nasal hinge microkeratome flap in the other eye. In all eyes,...

PURPOSE To determine whether in vivo confocal microscopy (IVCM) of the cornea can be used for the label-free detection and monitoring of lymph vessels in live corneas. METHODS Parallel corneal hemangiogenesis and lymphangiogenesis was induced by the placement of a single suture in one cornea of male Wistar rats. Fourteen days after suture placement and under general anesthesia, laser-scanning...

PURPOSE Corneal haze is a well-known pathology associated with decreased corneal transparency and increased ocular scattering. Clinically, haze is typically estimated as the amount of backscattered light observed in a slit lamp examination while the small angle forward scattering cannot be directly observed. It was the purpose of this study to demonstrate a single-pass technique to objectively ...

In the present study, the effects of the acute and chronic oral administrations (po) of curcumin in the absence and presence of morphine and naloxone was investigated on the sensation of acute corneal pain in rats. Acute corneal pain was induced by the local application of hypertonic saline (5 M NaCl) on the corneal surface, and the number of eye wipes was then counted for 30 s. Subcutaneous (s...