Production of Saffron (Crocus sativus L.) is expanding in both the traditional and non-native areas Jammu Kashmir, India. A study was carried out to develop a cost-effective production system module at ARSSSS, SKUAST-Kashmir, Pampore determine suitable corm weight planting density for saffron. The treatments current includes 3 levels (W1= < 8g, W2= 8-12g W3 = >12g) 5 densities viz., 15 lakh den...

Carbon monoxide (CO) is endogenously produced by heme oxygenase (HO) and is involved in vascular, neural, and inflammatory responses in mammals. However, the biological activities of CO in nonmammalian vertebrates is unknown. To this extent, we used smooth muscle myography to investigate the effects of exogenously applied CO (delivered via a water-soluble CO-releasing molecule, CORM-3) on isola...

guaiacol peroxidases (gp) are haem-containing enzymes participating in many physiological processes in plants. the expression pattern of these enzymes is organ-specific and developmentally regulated. methods: the presence of gp activity in extract samples, prepared from crocus sativus l. corms that were either dormant or rooting for 3, 6 and 10 days, was investigated. results: kinetic studies r...

Carbon monoxide (CO)-releasing molecules (CORMs) are used to deliver CO, a biological ‘gasotransmitter’, in chemistry and biomedicine. CORMs kill bacteria culture animal models, but reportedly benign towards mammalian cells. CORM-2 (tricarbonyldichlororuthenium(II) dimer, Ru2Cl4(CO)6), the first widely commercially available CORM, displays numerous pharmacological, biochemical microbiological a...

Helicobacter pylori is a pathogen that establishes long life infections responsible for chronic gastric ulcer diseases and a proved risk factor for gastric carcinoma. The therapeutic properties of carbon-monoxide releasing molecules (CORMs) led us to investigate their effect on H. pylori. We show that H. pylori 26695 is susceptible to two widely used CORMs, namely CORM-2 and CORM-3. Also, sever...

A field experiment was conducted to determine the response of different doses of N and P2O5 on the growth and flower quality of gladiolus at farmer field district Quetta during the summer season 2008. Six treatments were included in the trial viz; T1 (125+100); T2 (125+200); T3 (150+100); T4 (150+200); T5 (175+100) and T6 (175+200) NP kg/ha were tested in four replicated randomized complete blo...

Carbon monoxide, a classical respiratory inhibitor, also exerts vasodilatory, anti-inflammatory, and antiapoptotic effects. CO-releasing molecules have therapeutic value, increasing phagocytosis and reducing sepsis-induced lethality. Here we identify for the first time the bacterial targets of Ru(CO)(3)Cl(glycinate) (CORM-3), a ruthenium-based carbonyl that liberates CO rapidly under physiologi...

We report a new R package implementing the clustering of regression models (CORM) method for clustering genes using gene expression data and provide data examples illustrating each clustering function in the package. The CORM package is freely available at CRAN from http://cran.r-project.org.

The physiological gaseous molecule, carbon monoxide (CO) becomes a subject of extensive investigation due to its vasoactive activity throughout the body but its role in gastroprotection has been little investigated. We determined the mechanism of CO released from its donor tricarbonyldichlororuthenium (II) dimer (CORM-2) in protection of gastric mucosa against 75% ethanol-induced injury. Rats w...

The development of carbon monoxide-releasing molecules (CO-RMs) in recent years helped to shed more light on the diverse range of anti-inflammatory and cytoprotective activities of CO gas. In this study, we examined the effect of a ruthenium-based water-soluble CO carrier (CORM-3) on lipopolysaccharide (LPS)and interferon(INF)-induced inflammatory responses in BV-2 microglial cells and explored...