Nonlinear and linear least squares were used to determine the best fi t curve that would describe the relationship between blood plasma copper levels and liver copper levels in cattle. Data analyzed contained 540 paired blood and liver samples from grade Hereford calves, heifers and cows, and purebred Guernsey cows. The relationship between plasma and liver copper can be described by a constant...

Metallothioneins take part in the homeostasis of the ions of the metals which are necessary for the proper metabolism of the organism (zinc, copper), in biosynthesis regulation of the zinc-containing proteins and also in the detoxication of metals from the tissues. They also protect the tissue from the effects of free radicals, radiation, electrophilic pharmacological agents used in the cancer ...

Wilson's disease is a rare but treatable condition with variable clinical presentations. Its diagnosis depends on a combination of clinical and laboratory findings. We evaluated the clinical and laboratory findings in children with Wilson's disease (WD). Twenty -seven children (4-14 years, 59.2 % male, 40.7% female) with confirmed WD were evaluated between 1994 and 2003 at Imam Khomeini Hos...

Copper sulfate was given to male rabbits intraperitoneally and the copper concentrations in the plasma, red cells and EtOH-CHCl3 treated fraction of the cells were determined. The concentration of copper in the plasma increased markedly and in the red cells increased slightly after administration of 1 mg copper/kg of body weight, while the copper level in the EtOH-CHCl3 treated fraction remaine...

Understanding the metal-binding properties and solution states of metallo-chaperones is a key step in understanding how they function in metal ion transfer. Using spectroscopic, bioanalytical and biochemical methods, we have investigated the copper-binding properties and association states of the putative copper chaperone of Bacillus subtilis, CopZ, and a variant of the protein lacking the two ...

The level at which copper becomes toxic is not clear. Several studies have indicated that copper causes oxidative stress; however, most have tested very high levels of copper exposure. We currently have only a limited understanding of the protective systems that operate in cells chronically exposed to copper. Additionally, the limits of homeostatic regulation are not known, making it difficult ...

Oral submucous fibrosis (OSMF) is a crippling disease that impedes the normal functions of the oral cavity. It is a slowly progressive disease characterized by epithelial atrophy, abnormal accumulation of collagen fibres in the sub-epithelial tissues leading to severe restriction of mouth opening and movement of the tongue. The disease is believed to be a localized collagen disorder. Chewing ar...

Copper homeostasis and distribution is strictly regulated by a network of transporters and intracellular chaperones encoded by a group of genes collectively known as copper homeostasis genes (CHGs). In this work, analysis of The Cancer Genome Atlas database for somatic point mutations in colorectal cancer revealed that inactivating mutations are absent or extremely rare in CHGs. Using oligonucl...

background: blindness due to cataract is a major and important problem in pakistan. the problem is expected to increase in future due to increase in tobacco smoking. the aim of study was to look for the mechanism associated with metal deposition and its effect on antioxidant enzymes in lens of smokers in karachi, pakistan. methods: 20 cataract patients were randomly selected from out patient de...