Inhibition of copper-mediated DNA damage has been determined for several polyphenol compounds. The 50% inhibition concentration values (IC(50)) for most of the tested polyphenols are between 8 and 480 μM for copper-mediated DNA damage prevention. Although most tested polyphenols were antioxidants under these conditions, they generally inhibited Cu(I)-mediated DNA damage less effectively than Fe...

Interesting and unexpected results on the cyanation of prochiral aldehydes catalyzed by chiral copper complexes of R-(+)/(S)-(-) α-ethylphenyl amine (I/II) in anhydrous methanol are presented. The cyanation reaction with chiral copper complexes of R-(+)/S-(-) α-ethylphenyl amines, acetols in methanol perform to afford a series of chiral products such as amines and acetonitriles (compounds 4-6, ...

Seleniumand sulfur-containing compounds can act as antioxidants by binding copper. To determine how this copper coordination results in the observed antioxidant activity, biologically relevant Cu and Cu complexes with the formulae [Cu(dmit)3] + (3), [Cu(dmise)4] + (4a), and [TpmCu(MISeox)] (6) (dmise = N,N′-dimethylimidazole selone; dmit = N,N′-dimethylimidazole thione; MISeox = bis(1methylimid...

Two new coumarin-based "turn-off" fluorescent probes, (E)-3-((3,4-dihydroxybenzylidene)amino)-7-hydroxy-2H-chromen-2-one (BS1) and (E)-3-((2,4-dihydroxybenzylidene)amino)-7-hydroxy-2H-chromen-2-one (BS2), were synthesized and their detection of copper(II) and iron(III) ions was studied. Results show that both compounds are highly selective for Cu²⁺ and Fe³⁺ ions over other metal ions. However, ...

We have found that copper(II) compounds containing a peptide group in the chelate exhibit high activity for modification or degradation of albumin in the presence of hydrogen peroxide, whereas no activity was detected for the copper(II) compounds without an amide-group. It is suggested that presence of the amide-group in the ligand may play an important role in the formation of a peroxide adduc...

The physiological and biochemical responses of two green algae Ankistrodesmus falcatus and Chlorella vulgaris to copper sulphate were investigated. In this experiment both Ankistrodesmus and Chlorella cultures were treated with copper sulphate concentrations ranging from 0. 5 to 250 μM. The influence of copper on growth and metabolism was determined. Ankistrodesmus grown at 250 μM copper sulpha...

Novel chemical entities (NCEs) may be investigated for emetic liability in a range of unpleasant experiments involving retching, vomiting or conditioned taste aversion/food avoidance in sentient animals. We have used a range of compounds with known emetic /aversive properties to examine the possibility of using the social amoeba, Dictyostelium discoideum, for research into identifying and under...

The instability of ascorbic acid in weakly acid solutions has recently been shown to be due to the copper content of the solutions (1). By strict elimination of copper, solutions of ascorbic acid are stable below pH 7.6. The preparation of copper-free reagents, however, is not very practical and in analytical procedures would not eliminate copper contamination from the materials analyzed. The u...