Mn and Fe BPMEN complexes showed excellent reactivity in catalytic oxidation with an excess of co-reagent (CH3COOH). In the straight line a cleaner system, volatile acetic acid was replaced by SiO2 (nano)particles two different sizes to which pending carboxylic functions were added (SiO2@COOH). The SiO2@COOH beads obtained functionalization nitrile (SiO2@CN) followed CN hydrolysis. All silica c...

The development of molecule-based switchable multifunctional materials remains an important challenge in molecular science. In particular, achieving high proton conductivities spin crossover (SCO) compounds is significant interest as the state can be controlled via transfer induced by electric field, which leads to magnetoelectric effects and spintronics. However, best our knowledge, no studies...

The MWCNTs-COOH Paste Electrode (MCPE) was successfully used to study the electrochemical behavior of temozolomide in 0.2 M H2SO4 solution, phosphate buffer solution (0.1M PBS, pH 7.4) and 0.1M NaOH solution by Cyclic Voltammetry (CV) technique. The results exhibit that MCPE can remarkably enhance sensing and electrocatalytic activity towards the oxidation and reductio...

Especially for cannabinoids, analytical procedures for the verification of recent use and generally for the assessment of the extent of drug abuse are of interest in clinical and forensic toxicology. For confirmation of abstinence, urine analysis seems to be a useful tool. Serial monitoring of THC-COOH to creatinine ratios can differentiate between recent drug use and residual THC-COOH excretio...

Intracellular ATP and membrane-associated phosphatidylinositol phospholipids, like PIP(2) (PI(4,5)P(2)), regulate the activity of ATP-sensitive K(+) (K(ATP)) and Kir1.1 channels by direct interaction with the pore-forming subunits of these channels. We previously demonstrated direct binding of TNP-ATP (2',3'-O-(2,4,6-trinitrophenylcyclo-hexadienylidene)-ATP) to the COOH-terminal cytosolic domai...

5-Carboxy-2'-deoxyuridine (5-COOH-2'-dUrd) is a product of the base-catalyzed hydrolysis of 5-trifluoromethyl-2'-deoxyuridine. Hydrolysis of 5-trifluoromethyl-2'-deoxyuridine to 5-COOH-2'-dUrd in phosphate-buffered saline was kinetically first order and was pH dependent. At 37 degrees C and pH 7.0, 7.5, and 8.0, hydrolysis occurred with rate constants of 4.19 x 10(-5), 9.30 x 10(-5), and 1.61 x...

The liver cytosolic enzyme, 10-formyltetrahydrofolate dehydrogenase (FDH) (EC 1.5.1.6) catalyzes two reactions: the NADP+-dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP+-independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate. The COOH-terminal domain of the enzyme (residues 420-902) is about 48% identical to a family of NAD...

Protein kinase D1 (PKD1) is a Ser/Thr kinase implicated in a wide variety of cellular responses. PKD1 activation is generally attributed to a PKC-dependent pathway that leads to phosphorylation of the activation loop at Ser(744)/Ser(748). This modification increases catalytic activity, including that toward an autophosphorylation site (Ser(916)) in a postsynaptic density-95/disks large/zonula o...

Density Functional Theory (DFT) calculations were employed to investigate the structural characteristics, electronic properties, and nonlinear optical properties of Benzyne-Based Chromophores at B3LYP/6-31G(d,p) level. The effects on the hyperpolarizabilities of various donor and acceptor substituent (H, F, Cl, Br, Me, NH2, OH, NH3+, COOH, CHO, CN, NO,NO2 ) were studied. The results reveale...

An efficient and reliable electrochemical sensing platform based on COOH-fMWCNTs modified GCE (COOH-fMWCNTs/GCE) was designed for the detection of nanomolar concentration Nile Blue Sulphate (NBS). In comparison to bare GCE, scaffold considerably enhanced peak current response NBS dye as confirmed from results voltammetric investigations. The approach detecting in droplet its solution dried over...