The Wnt and Notch signalling pathways regulate hair follicle maintenance, but how they intersect is unknown. We show that Notch signalling is active in the hair follicle pre-cortex, a region of high Wnt activity, where commitment to hair lineages occurs. Deletion of jagged 1 (Jag1) results in inhibition of the hair growth cycle and conversion of hair follicles into cysts of cells undergoing int...

burden of poverty and undernutrition among both adults and children.[2] TB has been called “phthisis” owing to profound wasting. In a book published in 1949, which reviewed the epidemiological risk factors for TB at a global level, Dr. JB McDougall of the WHO stated: “The nutrition of the individual using the term in its widest sense, is the most vital factor in the prevention of tuberculous di...

Two factors increase the motivation to adhere to a goal: goal commitment and lack of goal progress. When people ask about commitment, focusing on what they have accomplished (to date) signals to them high commitment and increases motivation. Conversely, when commitment is certain and people ask about goal progress, focusing on what they have yet to accomplish (to go) signals to them lack of pro...

The original description of Afraustraloderes rassei Bouyer, 2012 included a female that is now recognized as a separate species belonging to the genus Pixodarus and here described as Pixodarus spiniscapus sp. n. The true female of Afraustraloderes rassei has also been obtained recently and is, therefore, here described. The synonymy of Pixodarus exasperatus with Pixodarus nyassae, proposed earl...

In this study, we investigated the role of FK506 binding protein 51 (FKBP51) in human endometrial adenocarcinoma progression. Immunohistochemical analysis showed decreased FKBP51 expression in endometrial adenocarcinoma tissues. Moreover, higher FKBP51 expression was observed in the normal secretory phase than in proliferative-phase endometrial tissues. FKBP51-shRNA transfected KLE cells showed...

Communication with home can be beneficial to deployed service members' mental health, morale, and occupational effectiveness. Conversely a lack of communication with home increases the risk of developing mental health problems. Therefore it is important to ensure that communications media is both affordable and accessible while on deployment. However, contact with families can sometimes have ne...

In modern biomaterial design the generation of an environment mimicking some of the extracellular matrix features is envisaged to support molecular cross-talk between cells and scaffolds during tissue formation/remodeling. In bone substitutes chemical biomimesis has been particularly exploited; conversely, the relevance of pre-determined scaffold architecture for regenerated bone outputs is sti...

Single-process models of recognition memory posit that recognizing is based on a unidimensional value of global memory strength. By contrast, dual-process models propose the existence of two independent processes subserving the explicit recognition of previously encountered episodes, namely "familiarity" and "recollection." Familiarity represents a noncontextual form of recognition that may onl...

Two factors increase the motivation to adhere to a goal: goal commitment and lack of goal progress. When people ask about commitment, focusing on what they have accomplished (to date) signals to them high commitment and increases motivation. Conversely, when commitment is certain and people ask about goal progress, focusing on what they have yet to accomplish (to go) signals to them lack of pro...

We explicitly construct a collection of bad 3-orbifolds, $${\mathscr {X}}$$ , satisfying the following properties: Conversely, any 3-orbifold {O}}$$ contains some $$X \in {\mathscr as sub-orbifold; we call removing $$X$$ and capping resulting boundary cut-and-cap. Then by cutting-and-capping finitely many times obtain good orbifold.