BISHOP, JONATHAN S., NELSON D. GOLDBERG, AND JOSEPH LARNER. Insulin regulation of hepatic glycogen metabolism in the dog. Am. J. Physiol. 220(Z) : 499-506. 1971.-The effect of insulin on the activity of the glycogen-synthesizing and degrading enzymes was studied in serially collected biopsy samples of dog liver. In intact normal dogs infusion of glucose alone promoted activation of glycogen tra...

BACKGROUND Propofol is often combined with remifentanil for induction and maintenance of total intravenous anaesthesia. Target-controlled infusion (TCI) permits adapting infusion to pharmacokinetic models. In this study we compared depth of anaesthesia, haemodynamic variables and times to recovery in patients scheduled for lumbar microdiscectomy and receiving either manually controlled (group I...

Aim. A double-blind, randomized, placebo-controlled trial was designed to evaluate the efficacy of continuous intraoperative infusion of S(+)-ketamine under intravenous anesthesia with target-controlled infusion of remifentanil and propofol for postoperative pain control. Methods. Forty-eight patients undergoing laparoscopic cholecystectomy were assigned to receive continuous S(+)-ketamine infu...

OBJECTIVE The manual injection of a bolus of opioid in patients with brain injury induces an increase in intracranial pressure related to a decrease in mean arterial pressure. Such an effect has not been observed with the use of ketamine. The use of target-controlled infusion would minimize or suppress this adverse effect of opioid. This study evaluated the effects of an increase in plasma conc...

This study was designed to measure ischaemic pain during and after infusion of adenosine. In a double-blind, placebo-controlled, crossover study, eight ASA 1 male volunteers received infusion of adenosine 100 micrograms kg-1 min-1 or placebo for 10 min. This was repeated 1 week later with the alternate infusion. Pain measurements were made during tourniquet-induced ischaemia in an exercising ar...

OBJECTIVE The current meta-analysis examines the effects of ketamine infusion on depressive symptoms over time in major depressive disorder (MDD) and bipolar disorder (BD). METHODS Following a systematic review of the literature, data were extracted from 21 studies (n = 437 receiving ketamine) and analysed at four post-infusion time points (4 h, 24 h, 7 days and 12-14 days). The moderating ef...

Dentists often sedate patients in order to reduce their dental phobia and stress during dental treatment. Sedatives are administered through various routes such as oral, inhalation, and intravenous routes. Intravenous administration has the advantage of rapid onset of action, predictable duration of action, and easy titration. Typically, midazolam, propofol or dexmedetomidine are used as intrav...

background: it is not clear whether the use of volumetric peristaltic infusion pumps, affect the quality of the erythrocytes during packed cell transfusion or not. in the present study in vitro quality of red blood cells was assessed after using this type of infusion pumps in a prospective study. materials and methods: in this study 60 units of packed red cells were examined before and after pa...