frequent dosing of the potent anti-androgen, flutamide, is necessary to reach a therapeutic level for the treatment of prostatic carcinoma. sustained delivery of the drug could reduce the adverse effects such as gastrointestinal disorders and improve patient compliance. in the present study sustained-release matrix tablets of flutamide were prepared by direct compression method using different ...

Most data available from Paramecium, fewer from Tetrahymena, disclose essentially the same principles of signaling as in metazoans up to man. Microtubules serve for long-range signaling, whereas SNARE proteins, H-ATPase, GTPases and actin provide short-range molecular signals, with Ca as a most efficient, locally and spatially restricted signal particularly for membrane fusion. This is enabled ...

Non–universality in the soft breaking terms is a common feature in most superstring inspired SUSY models. This property is required to obtain sizeable CP violation effects from SUSY and, on the other hand, can be used to avoid the Electric Dipole Moment constraints. We take advantage of these qualities and explore a class of SUSY models based on type I string theory where scalar masses, gaugino...

The phenomena customly described with the standard ΛCDM model are broadly reproduced by an extremely simple model in TeVeS, Bekenstein’s (2004) modification of General Relativity motivated by galaxy phenomenology. Our model can account for the acceleration of the universe seen in SNeIa distances without a cosmological constant, and the accelerations seen rotation curves of nearby spiral galaxie...

Ambient Assisted Living aims at enhancing the quality of life of older and disabled people at home thanks to Smart Homes and Home Automation. However, many studies do not include tests in real settings, because data collection in this domain is very expensive and challenging and because of the few available data sets. The SWEET-HOME multimodal corpus is a dataset recorded in realistic condition...

BACKGROUND Patients with severe atopic dermatitis (AD) can benefit from cyclosporin (CSA) treatment. Some studies reported that CSA can cause infectious diseases as side effects. OBJECTIVE To investigate the possible association of CSA treatment in AD patients with infectious diseases. METHODS We performed a case-controled study on 202 patients with AD, 101 of whom were taking CSA and 101 w...

There is not a good biomaker that is closely related to survival time for bladder cancer(BLCA), The aim of the study is to identify a miRNA signature that could predict prognosis in BLCA patients according to the data from The Cancer Genome Atlas (TCGA). a total of 377 BLCA patients were finally enrolled in the study. The three miRNA signature was identified by Multivariate Cox proportional haz...

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