Innervation of the skeletal muscle involves local signaling, leading to acetylcholine receptor (AChR) clustering, and global signaling, manifested by the dispersal of preexisting AChR clusters (hot spots). Receptor tyrosine kinase (RTK) activation has been shown to mediate AChR clustering. In this study, the role of tyrosine phosphatase (PTPase) in the dispersal of hot spots was examined. Hot s...

BACKGROUND Staging of melanoma includes quantification of a proliferation index, i.e., presumed melanocytic mitoses of H&E stains are counted manually in hot spots. Yet, its reproducibility and prognostic impact increases by immunohistochemical dual staining for phosphohistone H3 (PHH3) and MART1, which also may enable fully automated quantification by image analysis. To ensure manageable workl...

We report Chandra X-ray Observatory and 1.4 GHz Australian Long Baseline Array (LBA) observations of the radio galaxy PKS 2153–69 and its environment. The Chandra image reveals a roughly spherical halo of hot gas extending out to 30 kpc around PKS 2153–69. Two depressions in the surface brightness of the X-ray halo correspond to the large scale radio lobes, and interpreting these as cavities in...

BACKGROUND To evaluate whether the location of moist desquamation matches high dose area for breast cancer patients receiving adjuvant radiotherapy (RT) after breast conservative surgery. METHODS One hundred and nine breast cancer patients were enrolled to this study. Their highest skin dose area (the hot spot) was estimated from the treatment planning. We divided the irradiated field into br...

Background: Iran detected its first COVID-19 case in February 2020 in Qom province, which rapidly spread to other cities in the country. Iran, as one of those countries with the highest number of infected people, has officially reported 1812 deaths from a total number of 23049 confirmed infected cases that we used in the analysis. Materials and Methods: Geographic distribution by the map of ca...

We present measurements with the VLBA of the variability in the centroid position of Sgr A* relative to a background quasar at 7mm wavelength. We find an average centroid wander of 71 ± 45μas for time scales between 50 and 100 min and 113± 50μas for timescales between 100 and 200 min, with no secular trend. These are sufficient to begin constraining the viability of the accretion hot-spot model...

LLE Review, Volume 143 125 Introduction In inertial confinement fusion (ICF),1 a shell of cryogenic deuterium (D) and tritium (T) filled with DT gas is imploded with direct laser illumination (direct drive)2 or through an x-ray bath produced inside a laser-irradiated hohlraum (indirect drive).3 Energy from the laser or x ray is absorbed in the plasma near the outer surface of the target, causin...

We present measurements with the VLBA of the variability in the centroid position of Sgr A* relative to a background quasar at 7mm wavelength. We find an average centroid wander of 71±45μas for time scales between 50 and 100 min and 113± 50μas for timescales between 100 and 200 min, with no secular trend. These are sufficient to begin constraining the viability of the hot-spot model for the rad...

MOTIVATION The O-ring theory reveals that the binding hot spot at a protein interface is surrounded by a ring of residues that are energetically less important than the residues in the hot spot. As this ring of residues is served to occlude water molecules from the hot spot, the O-ring theory is also called 'water exclusion' hypothesis. We propose a 'double water exclusion' hypothesis to refine...

PURPOSE Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are similar genetic disorders whose patterns of mutation and disease phenotypes might be expected to show differences among different countries. We analyzed multiplex ligation-dependent probe amplification (MLPA) data in a large number of Korean patients with DMD/BMD. MATERIALS AND METHODS We obtained 130 positive M...