BACKGROUND AND OBJECTIVES It has been reported that there is a high prevalence of immunodeficiency and autoimmunity in relatives of patients with common variable immunodeficiency (CVID). The aim of this study was to determine the prevalence of immunoglobulin deficiency in relatives of patients with CVID in Iran, where there is a high rate of consanguineous marriage. METHODS A descriptive stud...

Consanguinity or inter-cousin marriage is a phenomenon quite prevalent in certain regions around the globe. Consanguineous parents have a higher risk of having offspring with congenital disorders. It is difficult to model large scale consanguineous parental populations because of disparate cultural issues unique to regions and cultures across the globe. Although consanguinity has previously bee...

A consecutive sample of 5,000 families of Armed Forces personnel was analysed to study the prevalence of consanguineous marriage and its effect on the prevalence of hereditary gross (physical) malformations. The overall frequency of inbreeding was 76% with a coefficient of 0.04151 which is probably the highest figure reported in literature. The overall prevalence of congenital malformations in ...

OBJECTIVES Consanguinity is a wide spread practice in Jordan. The objective of this study is to explore the health effects of consanguinity, in particular fertility, reproductive wastage, infant mortality and congenital malformations. METHODS A stratified 2 stage cluster sample of 1867 married couples, representative of all population groups and all geographic locations of Jordan were randoml...

BACKGROUND We have investigated a strategy for identifying and counseling carriers of recessively inherited disorders in developing countries where consanguineous marriage is common. In such communities, gene variants are trapped within extended families, so that an affected child is a marker of a group at high genetic risk. METHODS Fifteen large Pakistani families, 10 with a history of a hem...

Congenital heart disorders (CHDs) are an important health issue due to heavy costs and emotional effects they impose to families and society. In general, the prevalence of CHDs is approximately 8 in 1000 newborn, with a multifactorial origin. On the other hand, previous studies have shown that the prevalence of CHDs is high among the children of parents with consanguineous marriage. The aim of ...