Cystic fibrosis (CF) airway epithelial cells are more susceptible to viral infection due to impairment of the innate host defense pathway of nitric oxide (NO). NO synthase-2 (NOS2) expression is absent, and signal transducer and activator of transcription (STAT) 1 activation is reduced in CF. We hypothesized that the IFN-gamma signaling pathway, which leads to NOS2 gene induction in CF airway e...

Bernhard Huchzermeyer Botanisches Institut, Tierärztliche Hochschule, Bünteweg 17d, D-3000 Hannover 71, Bundesrepublik Deutschland Z. Naturforsch. 43c, 213-218 (1988); received July 27/November 19, 1987 Chloroplast, Coupling Factor, Binding Sites, ATPase, Phosphorylation A single binding site for phosphate was found on isolated chloroplast coupling factor in the absence of nucleotides. In our e...

Abstract Background Different gamma camera calibration factor (CF) geometries have been proposed to convert SPECT data into units of activity concentration. However, no consensus has reached on a standardised geometry. The CF is dependent the selected geometry and further affected by partial volume effects. This study investigated effect two their corresponding recovery coefficients (RCs) quant...

The scaling of the kinematic boundary layer thickness λu and the friction factor Cf at the topand bottom-wall of Rayleigh-Bénard convection is studied by Direct Numerical Simulation (DNS). By a detailed analysis of the friction factor, a new parameterisation for Cf and λu is proposed. The simulations were made of an L/H = 4 aspect-ratio domain with periodic lateral boundary conditions at Ra = {...

Guinea pig peritoneal macrophages, when activated for cytotoxicity by the calcium ionophore A23187 or lipopolysaccharide, produce a cytotoxic factor [macrophage cytotoxic factor (M phi-CF)] that is not blocked by catalase or protease inhibitors. Fractionation of culture supernates containing M phi-CF by gel filtration revealed one peak of cytotoxic activity of Mr approximately 45,000, the same ...

Growth deficits are common in cystic fibrosis (CF), but their cause is complex, with contributions from exocrine pancreatic insufficiency, pulmonary complications, gastrointestinal obstructions, and endocrine abnormalities. The CF mouse model displays similar growth impairment despite exocrine pancreatic function and in the absence of chronic pulmonary infection. The high incidence of intestina...

To delineate the mechanisms that facilitate leukocyte migration into the cystic fibrosis (CF) lung, expression of chemokines, including interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), and RANTES, was compared between CF and non-CF airway epithelia. The findings presented herein demonstrate that, under either basal conditions or tumor necrosis factor-α (TNF-α)- and/or interfero...