نتایج جستجو برای: concomitant drug use
تعداد نتایج: 2253945 فیلتر نتایج به سال:
INTRODUCTION Integrating HIV and tuberculosis (TB) treatment can reduce mortality substantially. Practical barriers to treatment integration still exist and include safety concerns related to concomitant drug use because of drug interactions and additive toxicities. Altered therapeutic concentrations may influence the chances of treatment success or toxicity. AREAS COVERED The available data ...
Background: Opioid abuse is common in Iran. In recent years, methadone maintenance therapy (MMT) has gained popularity in this country. This study aimed at evaluation concurrent abuse of alcohol in patients under MMT. Methods: A predesigned questionnaire was developed and completed after obtaining verbal consent among 49 subjects under MMT in Kian Rehabilitation Centre during January 2014. Resu...
introduction and objectives: tuberculosis (tb) still remains a major health concern both in developing and developed countries. the rate of the liver injury due to anti-tb drugs in developed countries has been reported up to 4%. the goal of this study is to assess the rate and risk factors for anti-tuberculosis drug-induced liver injury (dili). also, a model has been designed to predict dili in...
In 1932, Prof. B. L. Mazur, growing a "blue stick" in broth, devoid of the acid resistance Koch stick, for first time received an atuberculin antivirus. The wand" and classic tuberculous mycobacterium do not grow Mazur's its environment, antivirus does contain tuberculin, it withstands sterilization autoclave well. These specific properties made possible to use clinic. patients with extrapulmon...
OBJECTIVE Assessing retention rate and risk factor for drug discontinuation is important for drug evaluation. We examined a 3-year retention rate and the risk factor for discontinuation due to insufficient efficacy (IE) and adverse events (AE) in Japanese patients with rheumatoid arthritis (RA) who are receiving etanercept (ETN). METHODS Data were collected from 588 patients treated with ETN ...
Ergotism is a rare cause of peripheral vasoconstriction with varying presentation depending on the affected vessels. Coronary vasospasm rare, potentially fatal manifestation ergotism. Cytochrome P-450 isoenzyme CYP3A metabolizes ergot alkaloids and their derivatives; thus, concomitant use ergotamine inhibitors significantly increases ergotism risk. The antiretroviral drug darunavir boosted cobi...
The pandemic of Coronavirus Disease 2019 (COVID-19) has now affected the entire globe which was first surfaced in China December 2019. In absence effective therapy to manage COVID-19, repurposed therapies were being used condition. view an urgent need for definitive therapy, multiple drugs, and investigational drug candidates are tried clinical trials may lead emergence unknown short term long ...
The incidence of hepatotoxicity related to trimethoprim/sulfamethoxazole (TMP/SMX) administered at a therapeutic dose may vary among study populations of different ethnicities and hepatotoxic metabolites of TMP/SMX may be decreased by drug-drug interaction with fluconazole. We aimed to investigate the incidence of hepatotoxicity and the role of concomitant use of fluconazole in HIV-infected pat...
Acetaminophen is a widely used analgesic that can cause acute liver failure when consumed above a maximum daily dose. Certain patients may be at increased risk of hepatocellular damage even at conventional therapeutic doses. We report a case of a 34-year-old man on carbamazepine for complex partial seizures who developed acute liver and renal failure on less than 2.5 grams a day of acetaminophe...
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