نتایج جستجو برای: comt

تعداد نتایج: 1925  

2016
Yvette N. Lamb Nicole S. McKay Shrimal S. Singh Karen E. Waldie Ian J. Kirk

The catechol-O-methyltransferase (COMT) val158met polymorphism affects the breakdown of synaptic dopamine. Consequently, this polymorphism has been associated with a variety of neurophysiological and behavioral outcomes. Some of the effects have been found to be sex-specific and it appears estrogen may act to down-regulate the activity of the COMT enzyme. The dopaminergic system has been implic...

2014
Andreas Ehler Jörg Benz Daniel Schlatter Markus G. Rudolph

Methylation catalysed by catechol-O-methyltransferase (COMT) is the main pathway of catechol neurotransmitter deactivation in the prefrontal cortex. Low levels of this class of neurotransmitters are held to be causative of diseases such as schizophrenia, depression and Parkinson's disease. Inhibition of COMT may increase neurotransmitter levels, thus offering a route for treatment. Structure-ba...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014
Zhijun Shen Yanming Wu Xiao Chen Xinwen Chang Qian Zhou Jian Zhou Hao Ying Jing Zheng Tao Duan Kai Wang

BACKGROUND 2-methoxyestradiol (2-ME), a natural metabolite of 17β-estradiol, is synthesized by catechol-O-methyltransferase (COMT). The aim of this study was to explore the maternal 2-ME concentration and placental COMT expression in the different trimesters of normal pregnancy and preeclamptic pregnancies, as well as the effects of 2-ME on cell proliferation and migration of HTR-8/SVneo under ...

2016
Min Jung Koh Jee In Kang Kee Namkoong Su Young Lee Se Joo Kim

PURPOSE Alexithymia, defined as a deficit in the ability to recognize and describe one's own feelings, may be related to the development and maintenance of obsessive-compulsive symptoms. The aim of this study was to evaluate the association between the catechol-O-methyltransferase (COMT) Val¹⁵⁸Met polymorphism and alexithymia in patients with obsessive-compulsive disorder (OCD). MATERIALS AND...

Journal: :Acta medica Okayama 1984
Chun-Hwi Tai Ruey-Meei Wu

Parkinson's disease (PD) is one of the main causes of neurological disability in the elderly. Levodopa is the gold standard for treating this disease, but chronic levodopa therapy is complicated by motor fluctuation and dyskinesia. The catechol-O-methyltransferase (COMT) inhibitors represent a new class of antiparkinsonian drugs. When coadministered with levodopa/decarboxylase inhibitor, 2 COMT...

Journal: :International journal of molecular medicine 2008
Hyoung-Woo Bai Pan Wang Bao Ting Zhu

Human catechol-O-methyltransferase (COMT, EC 2.1.1.6) catalyzes the transfer of the methyl group to a variety of endogenous and exogenous catechol substrates using S-adenosyl-L-methionine as the methyl donor. This enzymatic O-methylation plays an important role in the inactivation of biologically-active and toxic catechols. A number of studies in recent years have sought to characterize the pol...

2015
Liang-Jen Wang Sheng-Yu Lee Shiou-Lan Chen Yun-Hsuan Chang Po See Chen San-Yuan Huang Nian-Sheng Tzeng Kao Chin Chen I. Hui Lee Tzu-Yun Wang Yen Kuang Yang Ru-Band Lu

Bipolar II disorder (BP-II), characterized by recurrent dysregulation of mood, is a serious and chronic psychiatric illness. However, BP-II is commonly under-recognized, even in psychiatric settings. Because dopaminergic disturbance is thought to be involved in the development of bipolar disorder (BPD), it seems essential to investigate dopamine-related genes like the catechol-O-methyltransfera...

Journal: :Frontiers in Human Neuroscience 2008
Irene E. Nagel Christian Chicherio Shu-Chen Li Timo von Oertzen Thomas Sander Arno Villringer Hauke R. Heekeren Lars Bäckman Ulman Lindenberger

We demonstrate that common genetic polymorphisms contribute to the increasing heterogeneity of cognitive functioning in old age. We assess two common Val/Met polymorphisms, one affecting the Catechol-O-Methyltransferase (COMT) enzyme, which degrades dopamine (DA) in prefrontal cortex (PFC), and the other influencing the brain-derived neurotrophic factor (BDNF) protein. In two tasks (Wisconsin C...

Journal: :Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2008
Makoto Tsunoda

Catecholamines, namely, dopamine, norepinephrine and epinephrine, play important roles in higher animals as neurotransmitters or hormones, and are metabolized by catechol-O-methyltransferase (COMT). To elucidate the role of COMT in blood pressure regulation, we have developed simultaneous determination methods for catecholamines and their 3-O-methyl metabolites using high-performance liquid chr...

2014
James S. Woods Nicholas J. Heyer Joan E. Russo Michael D. Martin Pradeep B. Pillai Theodor K. Bammler Federico M. Farin

Mercury (Hg) is neurotoxic and children may be particularly susceptible to this effect. A current major challenge is identification of children who may be uniquely susceptible to Hg toxicity because of genetic disposition. This study examined the hypothesis that genetic variants of catechol-O-methyltransferase (COMT) that are reported to alter neurobehavioral functions that are also affected by...

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