The role of cerebellar pathology in psychiatric symptoms has long been recognized. Cerebellar pathology has been associated with obsessive-compulsive disorder pathophysiology, particularly with compulsive hoarding. Likewise, some cerebellum abnormalities have been described in schizophrenia, as well as in comorbidity between obsessive-compulsive disorder and schizophrenia. The authors report th...

Neuroimaging studies of obsessive-compulsive disorder have found abnormalities in orbitofronto-striato-thalamic circuitry, including the orbitofrontal cortex, anterior cingulate cortex, caudate, and thalamus, but few studies have explored abnormal intrinsic or spontaneous brain activity in the resting state. We investigated both intra- and inter-regional synchronized activity in twenty patients...

OBJECTIVE Changes in defense mechanisms after treatment of patients with obsessive-compulsive disorder (OCD) were measured by using an established rating scale. METHOD Before and after 7-week group behavior therapy, 17 patients with DSM-III-R OCD were assessed with the Defense Style Questionnaire, Yale-Brown Obsessive Compulsive Scale, and Beck Depression Inventory. RESULTS After behavior t...

OBJECTIVE To update clinicians regarding the existence of a putative subtype of obsessive-compulsive disorder based on poor insight. METHOD Opinionative review based on studies indexed in the PubMed and PsychINFO databases, identified by means of the keywords 'obsessive-compulsive disorder' AND 'insight' OR 'ego-syntonic', and published between 1966 and October 2009. The results were analyzed...

The relationship between obsessive compulsive disorder and psychotic state is intriguing. Early German authorities such as Bleuler shared the view put forward by Westphal that the entire obsessive compulsive syndrome is a variant or prodrome of Schizophrenia (Bleuler 1951). Many follow-up studies of patients who received an initial diagnosis of obsessive compulsive disorder have found variable ...

OBJECTIVE Prefrontal mechanisms are implicated in obsessive-compulsive disorder. The authors investigated whether prefrontal repetitive transcranial magnetic stimulation influenced obsessive-compulsive disorder symptoms. METHOD Twelve patients with obsessive-compulsive disorder were given repetitive transcranial magnetic stimulation (80% motor threshold, 20 Hz/2 seconds per minute for 20 minu...

Comorbidity is known to occur among various psychiatric disorders. About the third of the patients with Obsessive Compulsive Disorder have major depressive disorder and anxiety disorder but coexistence of Obsessive Compulsive Disorder with mania is rare to see. Here we report a case of Obsessive Compulsive Disorder where manic phase was accompanied by obsessions of contamination and pathologica...

obsessive-compulsive disorder (ocd) is a psychiatric disorder manifested by thoughts and impulses that produce anxiety and result in patients performing repetitive rituals. treatment generally consists of cognitive behavioral intervention and serotonin reuptake inhibitors. up to 40% of patients will have functional impairment that significantly affects their quality of life. in the late 1990’s,...