Nanostructured surfaces enhance ion yields in matrix-assisted laser desorption–ionization mass spectrometry (MALDI-MS). The spike protein complex, S1, is one fingerprint signature of Sars-CoV-2 with a 75 kDa. Here, we show that MALDI-MS ions the 100 kDa range are enhanced 50-fold when matrix–analyte solution placed on substrates coated dense forest multi-walled carbon nanotubes, compared to fro...

A new configuration of dielectric-loaded resonator (DR), particularly versatile for the complex permittivity measurement substrates microwave circuits, even in presence back metal plates, is shown here. To test this technique a wide interval values permittivity, versatility 3-D printing exploited to print samples with different densities, thus artificially changing effective (1.7–3.1) real part...

A robust protocol for the CuI-catalysed arylation of amidines is presented. Whilst the initially identified conditions were useful for benzamidine-derived substrates, difficulties were encountered with more complex substrates. This problem was overcome following a change in ligand type, enabling the synthesis of analogues of the chemical tool, blebbistatin.