1. By complement fixation tests, it has been clearly demonstrated that the sera of rabbits immunized with inulin, soluble starch and dextrine contain specific antibodies. 2. All these immune sera gave a negative precipitation reaction. 3. The kind of dextrine which has a construction very near to starch has an antigenic property, but those in a state of further decomposition do not give rise to...

Antigens derived from three different yeast strains of Histoplasma capsulatum (GW and VC used by the Veterans Administration Serology Reference Laboratory and the Centers for Disease Control reference antigen, A811) were compared with each other to determine their equivalency. Results from 200 sera, tested concurrently by the Serology Reference Laboratory and the University of Kentucky Mycosero...

In a previous communication (Shaw, 1955), I referred to several papers concerning the value of cardiolipin antigen in complement-fixation and flocculation tests. The majority of workers have reported increased sensitivity and specificity with this antigen, which has also been recommended to obtain reproducible results in various laboratories in different countries. At that time, I compared the ...

An immunohistologic complement fixation test has been used in an effort to detect immune complexes in sections of kidney from rats injected with rabbit anti-rat kidney serum and in sections of biopsied kidneys from four humans with membranous glomerulonephritis. Sections of the rat and human kidneys were treated with fluorescein-conjugated anti-rabbit globulin or antihuman globulin respectively...

Bordet and Gengou (1), in 1906, performed serological tests on pertussis employing the organisms which they discovered and claimed to be the causative agent of whooping cough as the antigen for the complement fixation test. They got a positive reaction in most cases of the disease. Yet, later investigations failed to confirm these results. Among those who confirmed their results were Renaux (2)...

Infection with poliomyelitis virus gives rise to complement-fixing (C-F) antibodies which may be detected with antigens prepared either from the brains of infected mice or tissue culture fluids, as shown with Type II by Casals et al."' and with all three types by Svedmyr et al.' These workers used sufficient antigen in each test to obtain maximum sensitivity. With this antigen concentration the...

Much has been done, but there is still much to be accomplished in the matter of tests for infection and immunity in leprosy. To be of help to the clinicians it is not sufficient for a test to be positive among the inmates of a leper asylum; it is necessary that it should work also in free surroundings where are met the doubtful cases, toward the' detection of which the greatest vigilance should...