Received 9 September 2012 Accepted 8 October 2012 ABSTRACT Background Several recent trials in chronic obstructive pulmonary disease (COPD) have assessed the effectiveness of the fluticasone–salmeterol combination inhaler in preventing COPD exacerbations, while finding an increased risk of pneumonia. The number needed to treat (NNT) is a simple measure to perform the comparative benefit–risk im...

Abstract Background To describe lemborexant and daridorexant for insomnia treatment using number needed to treat (NNT), harm (NNH), likelihood be helped or harmed (LHH). Methods Dichotomous outcomes were identified from the two registrational randomized controlled trials. Analogous data then extracted registration studies. Results Using pooled dosage data, had a clinically relevant magnitude of...

Purpose: Alzheimer’s disease (AD) is considered as one of the most dangerous diseases in present scenario. It a brain disorder which leads to destruction thinking skills and memory human beings. very much essential for early classification AD magnetic resonance imaging (MRI) preprocessed images (ADMPIs) into several categories such Mild_Demented (MID), Moderate_Demented (MOD), Non_Demented (ND)...

BACKGROUND The number needed to treat (NNT) ratio is an effective method for measuring accuracy in melanoma detection. Dermoscopy reduces the number of false positives and subsequently unnecessary excisions. In vivo reflectance confocal microscopy (RCM) is a noninvasive technique that allows examination of the skin with cellular resolution. OBJECTIVES To assess the impact of RCM analysis on t...

BACKGROUND Droxidopa is an orally active prodrug that significantly improved dizziness/lightheadedness measured using the Orthostatic Hypotension Symptom Assessment (OHSA) Item 1 in patients with neurogenic orthostatic hypotension (nOH) caused by primary autonomic failure (Parkinson disease, multiple system atrophy, and pure autonomic failure), dopamine β-hydroxylase deficiency, or nondiabetic ...

BACKGROUND The causes of bronchopulmonary dysplasia (BPD) are multifactorial. Overdistension of the lung (volutrauma) is considered an important contribution. As an alternative to traditional pressure-limited ventilation (PLV), modern neonatal ventilators offer modes which can target a set tidal volume. OBJECTIVES To determine whether volume-targeted neonatal ventilation, compared with PLV, r...

This article subjects a randomized controlled trial published in the American Journal of Psychiatry to a methodological and statistical critique, including a re-analysis of the effect size statistics presented. The published trial tested the use of combination antidepressants (mirtazapine co-prescribed with either buproprion, venlafaxine, or fluxoetine) at treatment initiation as compared to fl...

BACKGROUND: Hypertension is among the most common chronic condition in middle-aged and older adults. Approximately 50 million Americans are currently diagnosed with this condition, and more than $18.7 billion is spent on hypertension management, including $3.8 billion for medications. There are numerous pharmacological agents that can be chosen to treat hypertension by physicians in clinical pr...