conclusion a high rate of mrsa in both community- and hospital-acquired infections were observed. background staphylococcus aureus (s.aureus) is an importantpathogen in human infections.some strains of s.aureusare methicillin-resistant (mrsa) andcause hospital- and community-acquired infections in children. the aims of this study were to determine nasalcarriage rate of s. aureus and susceptibil...

BACKGROUND Endocarditis may precede or complicate bacterial meningitis, but the incidence and impact of endocarditis in bacterial meningitis are unknown. METHODS AND RESULTS We assessed the incidence and clinical characteristics of patients with meningitis and endocarditis from a nationwide cohort study of adults with community-acquired bacterial meningitis in the Netherlands from 2006 to 201...

Community-acquired meningitis caused by P. aeruginosa is rare and has a very high mortality rate. Early recognition and treatment is of paramount importance. We describe a case of a 75-year-old male with a P. aeruginosa meningitis which was linked to a regional swimming pool. Physicians should be aware that treatment according to the Dutch meningitis guidelines does not include coverage of infe...

BACKGROUND Community-acquired acute bacterial meningitis is a life-threatening infection and many outbreaks have been reported all around the world. METHODOLOGY We analysed 330 cerebrospinal fluid (CSF) samples received over a period of eight months from patients older than one month. Microscopy, cultures, identification, and antigen detection were performed for the positive samples. RESULT...

Acute bacterial meningitis (ABM) is a potentially life-threatening neurological emergency. An agreed protocol for early, evidence-based and effective management of community-acquired ABM is essential for best possible outcome. A literature search of peer-reviewed articles on ABM was used to collect data on the management of ABM in older children and adults. Based on the strength of published ev...

BACKGROUND Community-acquired bacterial meningitis (CABM) continues to have a high mortality rate and often results in severe sequelae among survivors. Lately, an increased effort has been focused on describing the neurological complications of meningitis including hydrocephalus. To aid in this field of research we set out to ascertain the risk and outcome of hydrocephalus in patients with comm...

BACKGROUND A high dose of anti-infective agents is recommended when treating infectious meningitis. High creatinine clearance (CrCl) may affect the pharmacokinetic / pharmacodynamic relationships of anti-infective drugs eliminated by the kidneys. We recorded the incidence of high CrCl in intensive care unit (ICU) patients admitted with meningitis and assessed the diagnostic accuracy of two comm...