Purpose of review When leveraging observational data to estimate treatment effects, it is useful to explicitly specify the "target trial" the investigators aspire to emulate. One concern is whether a proposed analysis plan can address the realities of the differences between the available non-randomized observational study and the target trial. When large or unknown sources of unmeasured confou...

Given the increasing complexity of the tasks and skills needed in modern society, developing effective training strategies is of tremendous practical importance. Furthermore, training that improves performance of both trained and untrained tasks would be highly efficient. In the present study, we examined how directed training contributes to skill acquisition, and more importantly, to engenderi...

The effects of reinforcement on delayed matching to sample (DMTS) have been studied in two within-subjects procedures. In one, reinforcer magnitudes or probabilities vary from trial to trial and are signaled within trials (designated signaled DMTS trials). In the other, reinforcer probabilities are consistent for a series of trials produced by responding on variable-interval (VI) schedules with...

The present study tested a formal, or purely mathematical, theory of matching, and a modern account derived by McDowell (1986) that incorporates deviations from strict matching-bias and sensitivity. Six humans pressed a lever for monetary reinforcers on five concurrent variable interval (VI) schedules of reinforcement. All schedules were presented during each session. The magnitude on one alter...

BACKGROUND There is considerable recent interest in the monitoring of individual surgeon or hospital surgical outcomes. If one aggregates data over time and assesses performance with a funnel plot, then the detection of any process deterioration or improvement could be delayed. The variable life adjusted display (VLAD) is widely used for monitoring on a case-by-case basis, but we show that use ...

BACKGROUND Mediation is an important issue considered in the behavioral, medical, and social sciences. It addresses situations where the effect of a predictor variable X on an outcome variable Y is explained to some extent by an intervening, mediator variable M. Methods for addressing mediation have been available for some time. While these methods continue to undergo refinement, the relationsh...

Derived pension rights exist in most Social Security systems but with variable generosity. They are mainly targeted towards non-working wives and widows and are viewed as a means to alleviate poverty among older women living alone. The purpose of this paper is to explain how they can emerge from a political economy process when the Social Security is a combination of Bismarckian and Beveridgian...

In randomized controlled trials, the intention-to-treat estimator provides an unbiased estimate of the causal effect of treatment assignment on the outcome. However, patients often want to know what the effect would be if they were to take the treatment as prescribed (the patient-oriented effect), and several researchers have suggested that the more relevant causal effect for this question is t...

The tension between exploitation of the best options and exploration of alternatives is a ubiquitous problem that all organisms face. To examine this trade-off across species, pigeons and people were trained on an eight-armed bandit task in which the options were rewarded on a variable interval (VI) schedule. At regular intervals, each option's VI changed, thus encouraging dynamic increases in ...

We propose a scheme to test Bell's inequalities for an arbitrary number of measurement outcomes on entangled continuous-variable (CV) states. The Bell correlation functions are expressible in terms of phase-space quasiprobability functions with complex ordering parameters, which can experimentally be determined via a local CV-qubit interaction. We demonstrate that CV systems can give higher vio...