BACKGROUND Apathy is a common neuropsychiatric symptom in Alzheimer's disease (AD) dementia and mild cognitive impairment (MCI). Detecting apathy accurately may facilitate earlier diagnosis of AD. The Apathy Evaluation Scale (AES) is a promising tool for measurement of apathy in prodromal and possibly preclinical AD. OBJECTIVE To compare the three AES sub-scales - subject-reported (AES-S), in...

MOTIVATION Copy number variations (CNV) include net gains or losses of part or whole chromosomal regions. They differ from copy neutral loss of heterozygosity (cn-LOH) events which do not induce any net change in the copy number and are often associated with uniparental disomy. These phenomena have long been reported to be associated with diseases and particularly in cancer. Losses/gains of gen...

A strong negation in da Costa’s Cn systems can be naturally extended from the strong negation (¬∗) of C1. In [1] Newton da Costa proved the conectives {→, ∧, ∨, ¬∗} in C1 satisfy all schemas and inference rules of classical logic. In the following paper we present a proof that all logics in the Cn herarchy also behave classically as C1. This result tell us the existance of a common property amo...

In the mol-ecule of the title compound, C15H18N2OS2, the central S2C=C(CN)C moiety is planar (r.m.s. deviation = 0.029 Å). The C=O and C-CN groups are trans to each other across their common C-C bond. In the crystal, one classical and two 'weak' hydrogen bonds combine with borderline N⋯N and S⋯S contacts to form layers parallel to (10-2). One ethyl group is disordered over two positions with re...

This work validates the generalizability of MRI-based classification Alzheimer’s disease (AD) patients and controls (CN) to an external data set task prediction conversion AD in individuals with mild cognitive impairment (MCI). We used a conventional support vector machine (SVM) deep convolutional neural network (CNN) approach based on structural MRI scans that underwent either minimal pre-proc...

A common method to determine the order of minimal realization of a continuous linear time invariant descriptor system is to decompose it into slow and fast subsystems using the Weierstrass canonical form. The Weierstrass decomposition should be avoided because it is generally an ill-conditioned problem that requires many complex calculations especially for high-dimensional systems. The present ...

discrimination of regenerative cirrhotic nodules of the liver (cn) from hepatocellular carcinoma (hcc) is sometimes difficult. we examined the utility of agnor staining in this context. fifteen cases of hcc and 25 cases of cn were stained by agnor method and the mean agnor number for one hundred nuclei in each case was determined. there was a significant difference between the mean agnor counts...

The problems of nding a longest common subsequence and a shortest common supersequence of a set of strings are well-known. They can be solved in polynomial time for two strings (in fact the problems are dual in this case), or for any xed number of strings, by dynamic programming. But both problems are NP-hard in general for an arbitrary number k of strings. Here we study the related problems of...