Butyrate, a key short-chain fatty acid metabolite of colonic luminal bacterial action on dietary fiber, serves as a primary fuel for the colonocytes, ameliorates mucosal inflammation, and stimulates NaCl absorption. Absorption of butyrate into the colonocytes is essential for these intracellular effects. Monocarboxylate transporter 1 (MCT1) plays a major role in colonic luminal butyrate absorpt...

Introduction: Non-Hodgkin lymphoma represents 0.3% of colonic malignancies. It presents in older males with comorbid infection, autoimmune disease or immunosuppression. Presenting symptoms are often non-specific including abdominal pain, decreased appetite, weight loss and anemia. Colonic perforation or obstruction from primary colonic lymphoma is commonly reported after treatment with chemothe...

assessment of colonic transit time (ctt) in patients with chronic constipation

background: colorectal adenocarcinoma is one of the most prevalent and treatable malignancies of the gastrointestinal tract. recent in vitro studies have demonstrated the anticancer effect of calendula officinalis extract on a tumor cell line derived from colorectal cancers. the inhibitory effect of this extract ranges from 70- 100% and an in vitro study has demonstrated that calendula officina...

Nitrite-preserved meats (e.g., hot dogs) may help cause colon cancer because they contain N-nitroso compounds. We tested whether purified hot-dog-derived total apparent N-nitroso compounds (ANC) could induce colonic aberrant crypts, which are putative precursors of colon cancer. We purified ANC precursors in hot dogs and nitrosated them to produce ANC. In preliminary tests, CF1 mice received 1 ...

Mall, M., M. Bleich, J. Kuehr, M. Brandis, R. Greger, and K. Kunzelmann. CFTR-mediated inhibition of epithelial Na1 conductance in human colon is defective in cystic fibrosis. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G709–G716, 1999.—Cystic fibrosis (CF) patients show characteristic defects in epithelial ion transport, such as failure in cAMP-dependent Cl2 secretion. Because the c...

Dinning, P. G., P. A. Bampton, M. L. Kennedy, and I. J. Cook. Relationship between terminal ileal pressure waves and propagating proximal colonic pressure waves. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G983–G992, 1999.—The relationship between propagating distal ileal and proximal colonic motor patterns has not been systematically examined in humans. Our aim was to define the rel...

conclusions previous abdominal surgery, including previous colonic surgery, confers no added risk of conversion to an open operation, morbidity or mortality for patients undergoing laparoscopic colorectal surgery. the operative time however is longer (30 minutes) for patients with previous colonic surgery. results out of 718 patients 476 had no previous abdominal surgery (group a), whilst 190 p...

conclusions traf6 plays an important role in the onset of colon cancer; therefore, drugs targeting it may have great clinical significance in the treatment of this disease. results the positive expression rate of traf6 in tumor tissues was 66.7%, which was significantly higher than in normal paracancerous tissues (18.5%). the positive expression rate of traf6 was significantly correlated with d...