Objective: This study examined subsite-specific colorectal cancer incidence rates and stage distributions for Asians and Pacific Islanders (API) and compared the API data with data for Whites and African Americans. Methods: Data included 336,798 invasive colorectal cancer incident cases for 1995 to 1999 from 23 population-based central cancer registries, representing about two thirds of API pop...

CA19.9 antigen is a glycoprotein present in human serum and found elevated in various diseases. It is intensively studied since long time as a potential marker for managing cancers of the gastrointestinal tract, but its reliability is widely accepted only for pancreatic cancers. Here, we focused on the tetrasaccharide epitope (NeuAcα2-3Galβ1-3[Fucα1-4]GlcNAc) sialyl-Lewis a studying the biosynt...

BACKGROUND & AIMS Gene silencing via promoter hypermethylation is a central event in the pathogenesis of cancers. To identify novel methylation targets in colon cancer, we conducted a genome-wide, microarray-based, in silico, and epigenetic search. METHODS Complementary DNA microarray experiments were first performed to identify genes down-regulated in primary colon cancers and up-regulated i...

Objective: Breast cancer is the most prevalent malignant disease among women and ranks top three common cancers globally, alongside lung colon cancer. Various subtypes of breast have been identified. Primary neuroendocrine cancer, a rare distinct type carcinoma, lacks specific radiological findings. The definitive diagnosis achieved through expression Synaptophysin Chromogranin A on tumor biops...

Background Post-surgical colonoscopic surveillance is recommended every 1-2 years for patients diagnosed with colon cancer and Lynch syndrome. Patients electing to have a segmental versus colectomy IRA risk developing metachronous colon cancers. The rationale for frequent surveillance is to detect and remove polyps before pathologically advancing to cancer thereby reducing mortality. Does compl...

Simultaneous laparoscopy-assisted resection for synchronous stomach and colon cancers has been reported frequently; however, robot-assisted gastrectomy and colectomy for these conditions are rarely reported. We report the successful use of robotic surgery for synchronous cancers of the stomach and colon. A 71-year-old woman with no specific medical history was diagnosed with early gastric cance...

Adenocarcinomas of rectum and colon may be different with regard to the cellular biological basis for cancer development. A material of 246 rectal cancers removed surgically at Akershus University Hospital in the years 1992-2000 was investigated and was compared to a material of 219 colon cancers operated on at Akershus University Hospital during the years 1988, 1990 and 1997-2000. There were h...

Colon cancer is the second leading cause of cancer-related death in the Western world. Approximately 80-90% of colon cancers develop in adenomas after mutations. The risk of encountering malignancy increases with the size of the adenomatous polyp. It is approximately 1% in adenomas <1 cm, and increases to 10% for adenomas 1-2 cm, and 20-53% for adenomas >2 cm. CT colonography (CTC) is a new tec...