نتایج جستجو برای: colon adenocarcinoma
تعداد نتایج: 130335 فیلتر نتایج به سال:
background: proliferation and expansion of cancer stem cells as spheroids were proved in previous studies. but, capability of primary tumor-derived stem cells to keep their unique properties in vitro is still disputed. so, the goal of this study was to isolate, expand and characterize of colon cancer-derived stem cells. material and methods: in the present work, colon cancer stem cells markers ...
Heterotopic gastric mucosa occurs in all areas of the gastrointestinal tract including the nasopharynx, tongue, esophagus, small intestine, colon, and rectum. Gastric heterotopia of the large bowel is infrequent, and most cases have been reported in the rectum. Review of the literature has revealed only eight cases involving the colon proximal to the rectum. Little is known of the natural histo...
The purpose of this study was to compare the expression of O-acetylated sialic acids on normal colonie epithelial cells to that on primary and metastatic human adenocarcinoma of the colon and rectum. In 24 cases, the relative percentages of biosynthetically labeled non-, mono-, di-, and tri-O-acetylated sialic acids were measured after hydrolytic release, separation, and identification by paper...
Angiopoietin-like protein 4 (ANGPTL4/FIAF) has been proposed as a circulating mediator between the gut microbiota and fat storage. Here, we show that transcription and secretion of ANGPTL4 in human T84 and HT29 colon adenocarcinoma cells is highly induced by physiological concentrations of short-chain fatty acids (SCFA). SCFA induce ANGPTL4 by activating the nuclear receptor peroxisome prolifer...
The assessment of the degree or rate of cellular proliferation and cell viability is critical for the assessment of the effects of drugs on both normal and malignant cell populations. In the present study, a few novel 3-substituted derivatives of 2-indolinones were synthesized by condensation of substituted oxindole or isatin derivatives with appropriate aldehydes or primary aromatic amine...
Surface epithelial tumors constituted 65.7% of all the ovarian tumors. Brenner tumors are a type of surface epithelial tumors that constitute 1 % to 3% of all ovarian neoplasms. The average age of presentation of Brenner tumors is about age 50 and 7 I % of the patients are over 40. Most patients are asymptomatic but abnormal uterine bleeding is the most common presenting symptom. Associated end...
Lymph node swelling in the setting of malignancy generally suggests metastasis of the primary tumor. A granulomatous reaction, i.e. sarcoid reaction, occurring within the lymph nodes draining carcinomas is a well-known but uncommon occurrence. The phenomenon is especially rarely seen in colon carcinoma. We herein report a rare case of a 56-year-old Japanese male with adenocarcinoma of the ascen...
Background and aims: Among all cancers, colon cancer is common and deadly, yet preventable. The estimated worldwide incidence of colon cancer is more than one million new cases per year. This study was done to identify the epidemiological features and risk factors of colon cancer in different regions of Birjand. Methods: This retrospective, descriptive an...
Arachidonic acid metabolism plays an important role in colon carcinogenesis. Cyclooxygenase-2 (COX-2), which catalyzes the rate-limiting step in the synthesis of prostaglandins from arachidonic acids, is known to be up-regulated in colon cancer, and multiple lines of evidence indicate that it is a critical early step in colon carcinogenesis. Recently, 15-lipoxygenase-1, the enzyme that converts...
A long non-coding RNA expression signature to predict survival of patients with colon adenocarcinoma
Colon cancer is the most common type of gastrointestinal cancer and is still the leading cause of cancer-related mortality worldwide. Long non-coding RNAs (lncRNAs) have been proved to be superior biomarkers in cancer diagnosis and prognosis than miRNAs and protein-coding genes. In the current study, our objective was to detect novel lncRNA biomarkers by analyzing lncRNA expression profiles and...
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