Protein is an essential component for life, and its synthesis is mediated by codons in any organisms on earth. While some codons encode the same amino acid, their usage is often highly biased. There are many factors that can cause the bias, but a potential effect of mononucleotide repeats, which are known to be highly mutable, on codon usage and codon pair preference is largely unknown. In this...

We generalise the problem of inverse reinforcement learning to multiple tasks, from multiple demonstrations. Each one may represent one expert trying to solve a different task, or as different experts trying to solve the same task. Our main contribution is to formalise the problem as statistical preference elicitation, via a number of structured priors, whose form captures our biases about the ...

Preference queries are relational algebra or SQL queries that contain occurrences of the winnow operator (find the most preferred tuples in a given relation). Such queries are parameterized by specific preference relations. Semantic optimization techniques make use of integrity constraints holding in the database. In the context of semantic optimization of preference queries, we identify two fu...

Preference queries are relational algebra or SQL queries that contain occurrences of the winnow operator (find the most preferred tuples in a given relation). We present here a number of semantic optimization techniques applicable to preference queries. The techniques make it possible to remove redundant occurrences of the winnow operator and to apply a more efficient algorithm for the computat...

Sequences of the gapA and ompA genes from 10 genera of enterobacteria have been analyzed. There is strong bias in codon usage, but different synonymous codons are preferred at different sites in the same gene. Site-specific preference for unfavored codons is not confined to the first 100 codons and is usually manifest between two codons utilizing the same tRNA. Statistical analyses, based on co...

The design and implementation of advanced personalized database applications requires a preference-driven approach. Representing preferences as strict partial orders is a good choice in most practical cases. Therefore the efficient integration of preference querying into standard database technology is an important issue. We present a novel approach to relational preference query optimization b...

In a market-oriented service computing environment, both back-end SLA (service level agreement) offers and front-end SLA requirements should be considered when performing service composition. In this paper, we address the optimization problem of SLA-constrained service composition and focus on the following issues: the difficulties related to preference definition and to weight assignment, the ...

Eighty-five cDNA clones for gamma-zein (proline-rich zein) from a cDNA expression library were isolated using specific antibody and cDNA probes. Nucleotide sequences of seven independent clones were determined and found to be identical in regions where they overlapped. The primary structure of the mature protein, determined from the sequence of one near full-length clone, consists of 204 amino ...

objective: enterotoxigenic escherichia coli is considered as the most important agent of children diarrhea and mortality in developing countries. this bacterium causes 300-600 thousands of deaths in the children under 5 years of age per year. with difficulties in treatment as well as its wide prevalence, designing an effective vaccine against this microorganism is the objective of world health ...

We consider the problem of preference-based search for configurable products. We focus on example-based tools that interactively show both candidates (best options given current preferences) and suggestions to stimulate preference expression. Suggestions are generated to maximize the chance of eliciting further preferences using our lookahead principle. We present Probabilistic Constraint Optim...