نتایج جستجو برای: codon 72 polymorphism

تعداد نتایج: 213974  

Journal: :Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia 2011
Bianca Bianco Denise Maria Christofolini Ariel Brandes Tatiana Goberstein Lerner Rubens Paulo Gonçalves-Filho Angela Mara Bentes de Souza Caio Parente Barbosa

PURPOSE to evaluate the frequency of TP53 codon 72 polymorphism in infertile women with endometriosis, women with idiopathic infertility, controls and its relation to the disease. METHODS a case-control study that included 198 infertile women with endometriosis, 70 women with idiopathic infertility and 169 fertile women without endometriosis as control. Detection of TP53 codon 72 gene polymor...

2012
A. Doosti P. Ghasemi Dehkordi S. Taheri M. Banitalebi M. Mahmoudzadeh

The p53 tumor suppressor gene plays two important roles in genomic stability: blocking cell proliferation after DNA damage until it has been repaired, and starting apoptosis if the damage is too critical. Codon 72 exon4 polymorphism (Arg72Pro) of the P53 gene has been implicated in cancer risk. Various studies have been done to investigate the status of p53 at codon 72 for arginine (Arg) and pr...

Journal: :iranian journal of medical sciences 0
mehdi nikbahkt dastjerdi department of anatomical sciences, school of medicine, isfahan university of medical sciences, isfahan, iran.

background: the tumor suppressor gene tp53 (alias p53) located on chromosome 17 is involved in various cancers. case-control studies have shown that p53 codon 72 polymorphism modulates the prognosis and susceptibility to various malignancies. we undertook the present study to explore a possible association between mucinous and non-mucinous adenocarcinomas with different genotypes or alleles at ...

Journal: :International Journal of Biological Sciences 2006
Yao-Yuan Hsieh Chich-Sheng Lin

OBJECTIVE Mutated p53 gene is related to the instability of cell growth and cell cycle progression. We aimed to evaluate the association between endometriosis and p53 codon 11, 72 and 248 gene polymorphisms. PATIENTS AND METHODS Women were divided into two groups: (1) moderate/severe endometriosis (n=148), and (2) non-endometriosis groups (n=150). P53 gene polymorphisms include codon11 Glu/Gl...

Journal: :international journal of reproductive biomedicine 0
mehdi nikbakht dastjerdi roshanak aboutorabi bahram eslami farsani

background: endometriosis is a female health disorder that occurs when cells from the lining of the uterus grow in other areas of the body. the cause of endometriosis is unknown. objective: the purpose of this study was to investigate tp53 gene codon 72 polymorphism in women with endometriosis and compared it with healthy samples in isfahan. materials and methods: we undertook a case-control st...

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