Migrant populations of South Asian origin have a higher risk for chronic kidney disease than the native whites. Several formulas have been developed to estimate kidney function from serum creatinine concentration. However, none of these has been validated in the South Asian population, which generally has different muscle mass composition than whites. A population-based cross-sectional study wa...

BACKGROUND The effects of antiretrovirals on cystatin C-based renal function estimates are unknown. METHODS We analyzed changes in renal function using creatinine and cystatin C-based estimating equations in 269 patients in A5224s, a substudy of study A5202, in which treatment-naive patients were randomized to abacavir/lamivudine or tenofovir/emtricitabine with open-label atazanavir/ritonavir...

BACKGROUND Current HIV treatment guidelines recommend using the Cockcroft-Gault equation for drug dosing adjustments. The use of newer glomerular filtration rate (GFR) estimating equations for drug dosing and the appropriateness of physician antiretroviral dosing based on estimated kidney function have not been studied in an HIV-positive population. METHODS We evaluated concordance between me...

OBJECTIVES To validate the performance of the most commonly used formulas for estimation of glomerular filtration rate (GFR) against measured GFR during the index hospitalisation for ST-elevation myocardial infarction (STEMI). SETTING Single centre, methodological study. PARTICIPANTS 40 patients with percutaneous coronary intervention-treated STEMI were included between November 2011 and Fe...

BACKGROUND The gamma camera uptake method with Tc-99m-DTPA is simple and less time consuming for the determination of the glomerular filtration rate (GFR). However, its diagnostic accuracy is debated. Gates' method and predicted creatinine clearance method were compared with plasma clearance method with Tc-99m-DTPA for the measurement of GFR. MATERIALS AND METHODS Tc-99m-DTPA renography was p...

BACKGROUND Antiretrovirals (ARVs) could lead to clinically significant nephrotoxicity and as such will require dose adjustments in the presence of renal insufficiency. OBJECTIVE To explore renal function estimating equations as alternatives for glomerular filtration rate (GFR) measurement in a stable cohort of HIV-infected patients. METHOD In estimating renal insufficiency in Ghanaian HIV-i...

BACKGROUND Heart transplantation is an established treatment for advanced heart failure. However, chronic kidney disease (CKD) is an important long-term complication of all forms of organ transplantation other than renal. It has been shown that a GFR <60 ml/min is predictive of premature cardiovascular death. MATERIAL/METHODS The aim of this study was to assess the prevalence of kidney dysfun...

Introduction: Determination of renal function is particularly important when prescribing antibiotics to elderly patients. This study aims determine the correlation between estimated creatinine clearance and glomerular filtration rate, for a hospitalized population very patients, audit antibiotic errors.Material Methods: Retrospective cohort all patients ? 80 years with antibiotic. Creatinine wa...

OBJECTIVE To evaluate the effect on creatinine clearance (CG-CrCl, Cockcroft-Gault equation) of switching to boosted protease inhibitor (PI) monotherapy in patients receiving a triple drug antiretroviral regimen containing TDF. METHODS All patients who had received a TDF-containing regimen for at least one year and had been switched to PI monotherapy were included. A rapid decrease in CG-CrCl...