Thrombosis and transmission of viral diseases are the principal adverse effects of current replacement therapy for factor IX deficiency when using heat-treated concentrates of vitamin K-dependent coagulation factors. More highly purified factor IX preparations could decrease the risk of disease transmission, reduce patient exposure to allogeneic proteins, and reduce the risk of thrombosis. In t...

Objective(s): Haemostasis prevents blood loss following vascular injury. It depends on the unique concert of events involving platelets and specific blood proteins, known as coagulation factors. The clotting system requires precise regulation and coordinated reactions to maintain the integrity of the vasculature. Clotting insufficiency mostly occurs due to genetically inherited coagulation fact...

Background: The liver is the cornerstone of the coagulation system. The physiology of blood coagulation is closely linked to liver function as the liver synthesizes most of the factors of the coagulation cascade and fibrinolytic proteins. Objective: The objective of this study was to evaluate coagulation abnormalities associated with chronic liver diseases and determine the coagulation abnormal...

conclusions because a considerable number of idus in iran are receiving reduction services, tailoring services for prevention of hepatitis infection are necessary. results hcv infection was found to be primarily associated with female gender [odds ratio (or) 5.0, 95% confidence interval (ci) 2.0-10.0)], unmarried status (or 2.9, 95% ci 1.9-4.4), drug use for more than 10 years (or 2.7, 95% ci 1...

PURPOSE Although coagulation activation has been reported in chronic urticaria, data pertaining to detailed changes in coagulation factors and global coagulation status are lacking. The current study evaluated global coagulation status in patients with chronic urticaria using thrombin generation assay (TGA) and the levels of individual coagulation factors. METHODS Patients with chronic urtica...

Endothelial dysfunction, one of many causes arterial changes in end-stage kidney disease (kidney failure), is a likely link between early vascular aging and the risk thrombosis or bleeding this condition. To evaluate this, we compared links stiffness endothelial/coagulation factors 55 patients receiving hemodialysis therapy 57 age-/sex-matched control individuals. Arterial was assessed from car...

OBJECTIVE Activated inflammation and activated blood coagulation are believed to increase the risk of coronary thrombosis and are related. We therefore compared plasma IL-6 (a key cytokine in the inflammatory process), fibrin D-dimer (a marker of fibrin turnover), and coagulation factors VII and XIIa (initiators of extrinsic and intrinsic blood coagulation, respectively) as predictors of corona...

Zinc oxide nanoparticles (ZnO NPs) have many biomedical applications such as chemotherapy agents, vaccine adjuvants, and biosensors but its hemocompatibility is still poorly understood, especially in the event of direct contact of NPs with blood components. Here, we investigated the impact of size and surface functional groups on the platelet homeostasis. ZnO NPs were synthesized in two differe...