An update of Virchow's triad for thrombogenesis can be considered by reference to abnormalities in the endothelium/endocardium ('abnormal vessel wall'), abnormalities of haemorhelogy and turbulence at bifurcations,atheroma at vessel wall ('abnormal bloodflow') and abnormalities in platelet as well as the coagulation and fibrinolytic pathways ('abnormal blood constituents'). The constituents of ...

AMA Połaska P, Kowalik I, Kozar-Kamińska K, et al. Coagulation abnormalities as predictors of renal dysfunction in heart failure with reduced ejection fraction. Medical Studies/Studia Medyczne. 2023;39(2):148-158. doi:10.5114/ms.2023.129035. APA Połaska, P., Kowalik, I., Kozar-Kamińska, K., Górska, E., Demkow, U., & Leszek, P. (2023). Medyczne, 39(2), 148-158. https://doi.org/10.5114/ms.2023.12...

The necropsy findings in 21 patients on an intensive care unit, on whom coagulation studies had been performed immediately before death, were assessed. Eleven of the patients were retrospectively studied and 10 were reviewed consecutively in a prospective study. Fifteen patients (eight retrospective and seven prospective) had evidence of disseminated intravascular coagulation. Microthrombi were...

The term thrombophilia refers to an abnormality of blood coagulation that increases the risk of thrombosis. Such abnormalities represent one component of the triad (along with stasis and abnormalities of the vessel wall) put forward by Virchow in the 19th century to explain why thrombosis occurs. Thrombophilic abnormalities may be heritable (the topic of this review) or acquired, although both ...

Professor Eberhard F. Mammen greatly contributed to the understanding of the relationship between hemostatic abnormalities and liver diseases. The physiology of the hemostatic system is closely linked to liver function because the liver parenchymal cells produce most of the factors of the clotting and fibrinolytic systems. Acute or chronic hepatocellular diseases and hepatic failure including l...

Introduction: Emergency physicians must maintain a broad differential when seeing patients in the emergency department (ED). Occasionally, patient may have an undiagnosed, life-threatening medical condition not related to presenting chief complaint. It is imperative review all ordered laboratory tests and any available previous values assess for abnormalities that warrant further evaluation. Ca...

We have studied the coagulation status of eight patients with the Chediak-Higashi syndrome (CHS), both in the chronic and the accelerated phase of the disease. It has been shown that during the accelerated phase there are coagulation abnormalities. These abnormalities include a peripheral thrombocytopenia, minor alterations of liver clotting factors, and mainly a profound hypofibrinogenemia and...

Gaucher disease (GD) is an inherited lysosomal disorder, originating from deficient activity of the lysosomal enzyme glucocerebrosidase (GCase). Normally, GCase hydrolyzes glucocerebroside (GC) to glucose and ceramide; however, impaired activity of this enzyme leads to the accumulation of GC in macrophages, termed "Gaucher cells." Gaucher disease is associated with hepatosplenomegaly, cytopenia...

BACKGROUND A bleeding diathesis is a common feature of Noonan syndrome, and various coagulation abnormalities have been reported. Platelet function has never been carefully investigated. METHODS The degree of bleeding diathesis in a cohort of patients with Noonan syndrome was evaluated by a validated bleeding score and investigated with coagulation and platelet function tests. If ratios of pr...

Abnormalities that have been reported for platelet indices and function, coagulation factors and tests, and the fibrinolytic system in hypothyroidism are reviewed. These abnormalities, although usually of limited importance clinically, may occasionally lead to major bleeding episodes and to diagnostic confusion.