Borland, Colin, Bryan Mist, Mariella Zammit, and Alain Vuylsteke. Steady-state measurement of NO and CO lung diffusing capacity on moderate exercise in men. J Appl Physiol 90: 538–544, 2001.—Using a rapidly responding nitric oxide (NO) analyzer, we measured the steady-state NO diffusing capacity (DLNO) from end-tidal NO. The diffusing capacity of the alveolar capillary membrane and pulmonary ca...

We evaluated the topographic distributions of regional cerebral blood flow in 51 normal subjects (mean age 41 years) by the xenon-133 inhalation technique. Forty-five of these subjects were divided by age into young normals less than 30 years old (mean age 24 years), middle-aged normals 30-50 years old (mean age 40 years), and elderly normals greater than 50 years old (mean age 62 years); there...

Interest in documenting ways to predict anxious responding in panic disorder (PD) patients has proliferated recently in the literature. In the current study, two self-report measures were assessed to determine their relative utility in predicting responses to a panicogenic challenge. The Anxiety Sensitivity Index (ASI) and the Suffocation Fear Scale (SFS) were evaluated by correlating scores on...

Administration of different concentrations of CO2 is known to cause an increase in respiratory minute volume. This increase of ventilation in healthy subjects is directly related to the height of the inspired alveolar carbon dioxide tension. It has been shown, however, that in patients with emphysema and in those with mitral valvular disease the increment of minute volume is smaller than in the...

Changes of regional cerebral blood flow from rest to mental activation by a visually presented spatial reasoning test were measured during normo- and hypercapnia in 10 healthy subjects. Hypercapnia, elicited by inhalation of 6% CO2, resulted in similar flow increases in all 32 cortical regions measured. Increases of flow during testing were seen in post-central regions of the brain whether the ...

The effects of inhalation of low concentrations of CO:! have been investigated widely in man (1, 2, 3, 4). The effects produced by higher concentrations (7.5-10 per cent CO,) have been recorded incompletely and only upon small groups. To supplement our knowledge of the quantitative aspects of respiration and circulation it seemed worthwhile to measure the response of a large group of normal sub...

Transmembrane electrical measurements were performed on the isolated rabbit iris-ciliary body (I-CB) to study the direct effects of halogenated inhalation anesthetic agents on the ciliary epithelium. Addition of either halothane, enflurane, or isoflurane to the control 95% O2:5% CO2 gas mixture resulted in a dose-dependent decrease in the short-circuit current (SCC) and potential difference (PD...

STAHLMAN, M.,J. GRAY, W.C. YOUNG,AND F.M. SHEPARD. Cardiovascular response of the neonatal lamb to hypoxia and hypercapnia. Am. J. Physiol. 213(4): 899-904. 1967.-The effects of hypoxia and hypercapnia on the circulatory dynamics of the unanesthetized newborn lamb were evaluated. Hypoxia produced by inhalation of 8a/, 02 caused a marked increase in pulmonary arterial pressure and pulmonary vasc...

BACKGROUND AND PURPOSE Estimation of dynamic cerebral autoregulation from spontaneous fluctuations of arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV) is an attractive monitoring option for cerebral hemodynamic impairment. We evaluated the correlation coefficient index method in patients with severe obstructive carotid disease and compared it with transfer function analysis...