During the past five years, the PI has received funding from individual grants from the National Science Foundation and the National Security Agency, as follows: DMS 9500936 (Random Tilings, 1995-1998); DMS 9803249 (Research on Tilings, 1999-2003). He also received funding from the National Security Agency, the most recent of which was MDA904-00-1-0060. As part of these grants, the PI has also ...

During the past five years, the PI has received funding from individual grants from the National Science Foundation and the National Security Agency, as follows: DMS 9500936 (Random Tilings, 1995-1998); DMS 9803249 (Research on Tilings, 1999-2003). As part of these grants, the PI has also received REU Supplements. The PI received additional support from the VIGRE grants awarded by NSF to the Un...

Mutations affecting the conversion of PI3P to the signaling lipid PI(3,5)P(2) result in spongiform degeneration of mouse brain and are associated with the human disorders Charcot-Marie-Tooth disease and amyotrophic lateral sclerosis (ALS). We now report accumulation of the proteins LC3-II, p62 and LAMP-2 in neurons and astrocytes of mice with mutations in two components of the PI(3,5)P(2) regul...

Four novel diimine rhenium(I) carbonyl complexes with the formula [Re(CO)3(L)Br], where L = 2-(4-(9H-carbazol-9-yl)phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline (P1), 2-(4-(3,6-di-tert-butyl-9H-carbazol-9-yl)phenyl)-1H-imidazo-[4,5-f][1,10]phenanthroline (P2), 2-(4-(6-(9H-carbazol-9-yl)-9H-3,9-bicarbazol-9-yl)phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline (D1), and 2-(4-(3',6'-di-tert-butyl-6-(3...

BACKGROUND UNAIDS estimates that 34 million people are currently living with the human immunodeficiency virus (HIV) worldwide. Currently recommended regimens for initiating HIV treatment consist of either a non-nucleoside reverse transcriptase inhibitor (NNRTI) or ritonavir-boosted protease inhibitor (PI) combined with two nucleoside reverse transcriptase inhibitors (NRTIs). However, there may ...

Introduction. Hepatotoxicity is a concern in HIV/hepatitis C virus (HCV) coinfected patients due to their underlying liver disease. This study assessed the incidence of hepatotoxicity in HIV/HCV co-infected patients in two outpatient infectious diseases clinics. Methods. HIV/HCV co-infected adults were included in this retrospective study if they were PI or NNRTI naïve at their first clinic vis...

The impact of drug-drug interactions (DDIs) between interferon-free direct acting antiviral (DAA) regimens and antiretrovirals (ART) among HIV/HCV co-infected individuals in clinical practice settings is unknown. A single-center, retrospective chart review of co-infected patients was conducted from June 2014 to February 2015. Significant interactions between simeprevir (SMV), ledipasvir (LDV), ...

A more than 20000-fold purification of human serum lipoamidase is described. This was accomplished by (NH4)2SO4 precipitation and chromatography on DEAE-Sepharose, Blue Sepharose CL-6B and phenyl-Sepharose CL-4B, followed by preparative isoelectric focusing (IEF) and finally by gel-permeation chromatography. Co-precipitation and co-chromatography of lipoamidase and biotinidase activities with e...

Resonance Raman spectra of deoxy and carbonmonoxy leghemoglobin (Lb) are compared to the corresponding forms of human adult hemoglobin (HbA). It is found that the heme "core size" indicator line has nearly the same frequency for the two deoxyhemoglobins and the pi-electron density-sensitive line also falls at the same frequency. However, several other modes occur at very different frequencies i...

BACKGROUND We hypothesized that induction of general anesthesia using sevoflurane improves the accuracy of non-invasive hemoglobin (SpHb) measurement of Masimo Radical-7® Pulse CO-Oximetry by inducing peripheral vasodilation and increasing the perfusion index (PI). The aim of this study is to investigate the change in the SpHb and the PI measured by Rad7 during induction of general anesthesia u...