نتایج جستجو برای: cn
تعداد نتایج: 12926 فیلتر نتایج به سال:
BACKGROUND In transplant patients, current cyclosporine (CsA) dose monitoring with classic pharmacokinetics has demonstrated limitations. Evaluation of the activity of calcineurin (CN), the serine-threonine phosphatase enzyme target of CsA, has been proposed as a reliable way to optimize CsA dosing. METHODS CN activity was measured in whole blood in an attempt to overcome the high variability...
فیبروئین ابریشم بازیافتی با غلظت های مختلف 8، 10، 5/12 و (w/w) 13% در حلال N - متیل مورفولین N - اکساید حل شد و محلول های ریسندگی با غلظت های مختلف حاصل گردید. تاثیر انواع انعقادگرها شامل: متانول، اتانول و 1- پروپانول و همچنین دماهای ریسندگی 95، 110 و °C 120 در فرآیند ترریسی محلول فیبروئین ابریشم مورد بررسی قرار گرفت. استحکام در پارگی الیاف بدست آمده در غلظت ها و حمام های انعقاد مختلف (بدون اعم...
N K and 3d atom L absorption spectra of hexacyano complexes in solid K Fe(CN) , Na Fe(CN) , K Cr(CN) , 2,3 4 6 4 6 3 6 K Mn(CN) , K Fe(CN) , and K Co(CN) have been measured by detecting the total electron yield. The N K spectra of the 3 6 3 6 3 6 complexes are very similar and differ only in intensity of the lowest-energy absorption band. The intensity of this feature 32 systematically decrease...
Treatment of Ni(NCS)2(PMe2Ph)2 with organic isocyanides CN-R gave five-coordinate isocyanide Ni(II) complexes, Ni(CN-R)(NCS)2(PMe2Ph)2 (R = C6H3-2,6-Me2 (1), t-Bu (2)). Interestingly, the corresponding reaction of Ni(NCS)2(P(n-Pr)3)2 with 2 equiv. of CN-t-Bu gave an unusual compound, which exists as an ion pair of the trigonal bipyramidal cation [Ni(P(n-Pr)3)2(CN-t-Bu)3]2+ (3) and the dinuclear...
Cain/cabin1 is an endogenous inhibitor of calcineurin (Cn), a calcium-dependent serine/threonine phosphatase involved in various cellular functions including apoptosis. We show here that during apoptosis cain/cabin1 is cleaved by calpain at the carboxyl terminus to generate a cleavage product with a molecular mass of 32 kDa as a necessary step leading to Cn-mediated cell death. Mouse cain/cabin...
BACKGROUND MET is a proto-oncogene with its copy number (CN) alterations been reported in some cancers, but not in primary intestinal diffuse large B-cell lymphoma (PI-DLBL) yet. METHODS In this retrospective study, we performed histology and chart reviews, immunohistochemistry and quantitative polymerase chain reaction for MET CN alterations on 28 surgically resected PI-DLBLs. RESULTS Ther...
Fibroblast growth factor receptor 1 (FGFR1) has been noted to be amplified in a variety of squamous cell carcinomas (SCCa) of the head, neck, and lung and increased copy number (CN) is a predictor of poor outcomes. FGFR1 is a therapeutic target for lung SCCa and inhibition therapy is currently in clinical trials. Absolute quantification of FGFR1 from formalin fixed paraffin embedded (FFPE) tiss...
The reaction of cyanide, carbon monoxide, and ferrous derivatives led to the isolation of three products, trans- and cis-[Fe(CN)(4)(CO)(2)](2)(-) and [Fe(CN)(5)(CO)](3)(-), the first two of which were characterized by single-crystal X-ray diffraction. The new compounds show self-consistent IR, (13)C NMR, and mass spectroscopic properties. The reaction of trans-[Fe(CN)(4)(CO)(2)](2)(-) with Et(4...
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