In this work, we initially develop a parallelized multiscale, multidomain modeling scheme that directly reduces computation time requirements without compromising the accuracy of established chemical models for a batch protein crystallization process. Then, a double exponentially weighted moving average (dEWMA)-based model predictive controller (MPC) is applied to a multiscale model of a batch ...

Abstract Repeated temperature cycling of crystals from a conglomerate forming chiral substance suspended in their saturated solution has shown to be effective converting mixture both enantiomers into an enantiomerically pure state. While by now large number different setups been demonstrated, here we show for the first time how continuous flow cycler with recycle stream is capable establishing ...

The characterization of new process equipment often includes tedious experiments, particularly for (cooling) crystallization. This can be cost-intensive and time-consuming when the actual has to continuously operated gain insights. For multi-purpose plants that frequently change substance system, this especially laborious. In order accelerate generation data quasi-continuous filter belt crystal...

Abstract This paper mainly focuses on the problem of coarse grain bottom surface red copper horizontal continuous casting billet, and tries to thicken end crystallizer by combining numerical simulation industrial experiment, indirectly improves cooling strength billet solve coarseness. The results show that optimum diameter lower inlet sleeve was 14.2 mm, when increased from 11 mm intensity par...

The research results concerning continuous removal of phosphate (V) ions from solutions containing 1.0 or 0.20 mass % of phosphate (V) ions and 0.2 or 0.5 mg/kg of copper (II) ions using magnesium and ammonium ions addition are presented. Continuous reaction crystallization of struvite MgNH4PO4 × 6H2O ran both under stoichiometric conditions and at 20% excess of magnesium ions (pH 9,  900 s). ...

The academic literature on and industrial practice of control of solution crystallization processes have seen major advances in the past 15 years that have been enabled by progress in in-situ real-time sensor technologies and driven primarily by needs in the pharmaceutical industry for improved and more consistent quality of drug crystals. These advances include the accurate measurement of solu...