Four types of carbons (activated carbon, Maxsorb superactivated carbon, mesoporous templated carbon CMK-3, and graphene) were investigated as selective sorbents for adsorption of thiophene from its solution in n-octane. Graphene showed clearly the highest sulfur capacity. The relative sulfur capacities correlated well with the relative heats of adsorption. The carbene-type zigzag edge sites and...

Dracorhodin perchlorate inhibited proliferation of several tumor cell lines. The drug induced oligonucleosomal fragmentation of DNA in HeLa cells and increased caspase-3, -8, -9 activities followed by the degradation of caspase-3 substrates, inhibitor of caspase-dependent DNase, and poly-(ADP-ribose) polymerase. It also increased caspase-1 activity and a caspase-1 inhibitor, Ac-YVAD-cmk, and a ...

Down syndrome children with acute megakaryocytic leukemia (AMkL) have higher cure rates than non-Down syndrome acute myeloid leukemia (AML) patients treated with cytosine arabinoside (ara-C). Megakaryoblasts from Down syndrome AML patients are more sensitive in vitro to ara-C than cells from non-Down syndrome AML patients. Somatic mutations in the GATA1 transcription factor have been detected e...

Activation of the mitogen-activated protein (MAP) kinase pathway has been associated with both cell proliferation and differentiation. Constitutively activated forms of Mek (MAP kinase/Erk kinase) and Erk (MAP kinase) have been previously shown capable of inducing differentiation or proliferation in nonhematopoietic cells. To specifically examine the role of Erk activation in megakaryocytic gro...

BACKGROUND Acute megakaryocytic leukemia (AMkL) in Down syndrome (DS) children is uniformly associated with somatic GATA1 mutations, which result in the synthesis of a shorter protein (GATA1s) with altered transactivation activity compared to the wild-type GATA1. It is not fully established whether leukemogenesis and therapeutic responses in DS AMkL patients are due to loss of the wild-type GAT...

Murine monoclonal antibody (mAb) Lym-1 is an immunoglobulin G2a specific for certain human leukocyte antigen-DR variants expressed on the surface of malignant B cells. It has been proposed for serotherapy in patients with B lymphomas. We have previously shown that mAb Lym-1 synergizes with granulocyte macrophagecolony stimulating factor to promote Raji B-lymphoid cell lysis by human neutrophils...

A variety of metal nitrates were filled into the pores of an ordered mesoporous CMK-3 carbon matrix by solution-based impregnation. Thermal conversion of the metal nitrates into the respective metal oxides, and subsequent removal of the carbon matrix by thermal combustion, provides a versatile means to prepare mesoporous metal oxides (so-called nanocasting). This study aims to monitor the therm...

A mesoporous Li 4 Ti 5 O 12 /C nanocomposite is synthesized by a nanocasting technique using the porous carbon material CMK-3 as a hard template. Modifi ed CMK-3 template is impregnated with Li 4 Ti 5 O 12 precursor, followed by heat treatment at 750 ° C for 6 h under N 2 . Li 4 Ti 5 O 12 nanocrystals of up to several tens of nanometers are successfully synthesized in micrometer-sized porous ca...

PURPOSE To investigate whether interleukin-1beta-converting enzyme (ICE), a mammalian homologue of the Caenorhabditis elegans cell death gene ced-3, is involved in gamma-irradiation-induced apoptosis (programmed cell death) of human retinoblastoma cells. METHODS The induction of apoptotic cell death in human retinoblastoma cell lines WERI-Rb-1 and Y79 by gamma-irradiation was determined with ...

Organic carbonyl electrode materials of lithium batteries have shown multifunctional molecule design and high capacity, but have the problems of poor cycling and low rate performance due to their high solubility in traditional carbonate-based electrolytes and low conductivity. High-performance organic lithium batteries with modified ether-based electrolyte (2 m LiN(CF3SO2)2 in 1,3-dioxolane/dim...