We have reconstituted a eukaryotic leading/lagging strand replisome comprising 31 distinct polypeptides. This study identifies a process unprecedented in bacterial replisomes. While bacteria and phage simply recruit polymerases to the fork, we find that suppression mechanisms are used to position the distinct eukaryotic polymerases on their respective strands. Hence, Pol ε is active with CMG on...

The attitude dynamics of a spacecraft with a variable speed control moment gyroscope (CMG), in the presence of conservative external inputs, are derived using variational principles. A complete dynamics model, that relaxes some of the assumptions made in prior literature on control moment gyroscopes, is obtained. These dynamics equations show the complex nonlinear coupling between the internal ...

In this study, we used a set of hyperspectral Hyperion scenes and assessed the effects of differing spectral and spatial resolutions on MODIS-AVHRR vegetation index (VI) continuity. Hyperion scenes were processed to simulate atmospherically-corrected normalized difference vegetation index (NDVI) and 2-band enhanced vegetation index (EVI2) values at MODIS Climate Modeling Grid (CMG) and AVHRR Gl...

We have conducted an optical long-term monitoring survey of the majority of dwarf galaxies in the Local Group, with the Isaac Newton Telescope (INT), to identify the long period variable (LPV) stars. LPV stars vary on timescales of months to years, and reach the largest amplitudes of their brightness variations at optical wavelengths, due to the changing temperature. They trace stellar populati...

In this paper a new practical Attitude Control System is proposed, based on Control Moment Gyroscopes (CMG). These actuators can provide unique torque, angular momentum and slew rate capabilities to small satellites without any increase in power, mass or volume. This will help small satellites become more agile and maneuverable. Agility considerably increases the operational envelope and effici...

BACKGROUND This study investigated changes in the expression of cannabinoid (CB) receptors and the effects of CB1 and CB2 agonists on detrusor overactivity (DO) associated with bladder outlet obstruction (BOO) in rats. METHODS Male Sprague Dawley rats were randomly assigned to four groups (n = 10) in each group. The control group comprised sham-operated rats. A animals in the BOO, CB1 agonist...

In this article, we present a virtual control contraction metric (VCCM) based nonlinear parameter-varying approach to design state-feedback controller for moment gyroscope (CMG) track user-defined trajectory set. This VCCM (NL) stabilization and performance synthesis approach, which is similar linear (LPV) approaches, allows achieve exact guarantees of exponential stability -gain on NL systems ...

The initiation of eukaryotic DNA replication is a highly regulated process conserved from yeast to human. The past decade has seen significant advances in understanding how the CMG (Cdc45‐MCM‐GINS) replicative helicase is loaded onto DNA. However, very little was known on how this complex is removed from chromatin at the end of S phase. Two papers in a recent issue of Science [1], [2] show that...

FinFET and UTBSOI (or ETSOI) FET are the two promising multi-gate FET candidates for sub-22nm CMOS technology. The BSIM-CMG and BSIM-IMG are the surface potential based physical compact models for multi-gate MOSFETs. The BSIM-CMG model has been developed to model common symmetric double, triple, quadruple and surround gate MOSFET. The BSIM-IMG model has been developed to model independent doubl...