OBJECTIVE Evidence for an important role of advanced glycation end products (AGEs) in the development of atherosclerosis and cardiovascular disease beyond diabetes mellitus and renal disease is growing. Skin autofluorescence (SAF) is a validated noninvasive measure of tissue AGEs. We hypothesized that SAF is elevated in peripheral artery disease (PAD). METHODS AND RESULTS A case-control study...

We did an experimental study to investigate the effect of the thermal stress due to the heater for adjusting adaptive flying height (AFH) on the readability and instability of tunneling magnetoresistance (TMR) sensors. The slider head consists of a small heater nearby the read/write elements for controlling the clearance between the read/write elements and the recording medium of the magnetic r...

The control of CD4 expression is essential for proper T lymphocyte development. We have previously described a cis-acting silencer element required for repressing transcription of the CD4 gene. Here we report the cloning and characterization of a novel factor that binds to a critical functional site in the CD4 silencer. This factor, referred to as silencer-associated factor (SAF), is a member o...

We have purified to near homogeneity a novel nuclear protein from HeLa cells, that specifically binds to scaffold or matrix attachment region DNA elements (S/MAR DNA). The protein, designated SAF-B for scaffold attachment factor B, is an abundant component of chromatin, but not of the nuclear matrix and is expressed in all human tissues investigated. Antibodies against the purified protein were...

An advanced control strategy of shunt active filters (SAF) aiming to compensate for harmonic current in the electric supply grid is proposed. The SAF considered here is suitable for three-phase three-wire current harmonic compensation and is based on AC/DC three-phase boost converter topology. Robust control of the active-reactive current/power delivered by the SAF is designed exploiting the in...

The lack of information about core’s internal structure is The designers must rely solely on the test set distributed by the core provider. Sometimes the stuck at fault (SAF) model and automatic test pattern generation (ATPG) are used to generate test vectors for those pre-defined blocks. However, a SAF test set could waste lots of time to verify the pre-verified internal structure of the cores...

The purpose of this paper is to describe a new, user-friendly tool that will enable researchers and instructors to setup and run virtual environment scenarios that adapt to the VE user’s real-time performance and cognitive status. This tool, the Automated SAF Adaptation Tool (ASAT), will work with existing performance and cognitive state assessment software, and with existing semi-automated for...

Ionizing radiation (IR) induces highly cytotoxic double-strand breaks (DSBs) and also clustered oxidized bases in mammalian genomes. Base excision repair (BER) of bi-stranded oxidized bases could generate additional DSBs as repair intermediates in the vicinity of direct DSBs, leading to loss of DNA fragments. This could be avoided if DSB repair via DNA-PK-mediated nonhomologous end joining (NHE...

The aim of this study was to compare the efficacy of D-RaCe files and a self-adjusting file (SAF) system in removing filling material from curved root canals instrumented and filled with different techniques by using microcomputed tomography (micro-CT). The mesial roots of 20 extracted mandibular first molars were used. Root canals (mesiobuccal and mesiolingual) were instrumented with SAF or Re...

Symptomatic burden in myeloproliferative neoplasms is present in most patients and compromises quality of life. We sought to validate a broadly applicable 18-item instrument (Myeloproliferative Neoplasm Symptom Assessment Form [MPN-SAF], coadministered with the Brief Fatigue Inventory) to assess symptoms of myelofibrosis, essential thrombocythemia, and polycythemia vera among prospective cohort...