We have previously examined spatio-temporal dynamics of clot formation in vitro [Ataullakhanov et al., 2002]. Here we describe a mathematical model developed to analyze the obtained experimental results. This model is based on a modern view of the molecular pathways of blood coagulation. Most of the results, which led to this view, were obtained in the in vitro stirred systems and provided the ...

Many large, disease-related biobanks of serum samples have been established prior to the widespread use of proteomics in biomarker research. These biobanks may contain relevant information about the disease process, response to therapy or patient classifications especially with respect to long-term follow-up that is otherwise very difficult to obtain based on newly initiated studies, particular...

There have been conflicting reports as to whether the ingestion of fat increases the tendency for the blood to clot, and hence, by implication, the risk of thromboembolic complications in man. In this study the effect of a single meal containing a large amount of fat was compared with that of a practically purely carbohydrate isocaloric meal. Under carefully controlled conditions the clotting t...

By FRANK MALTANER, PH.D., AND JosE 0. DE ALMEIDA, M.D. T HE CLOSE relationship between the role of calcium in the clotting and complement activities of serum has already been shown.’ More recent studies have demonstrated the effect of magnesium in the hemolytic activity of complement’ and in the clotting reaction.3 Since it is well known that magnesium salts do not replace calcium in the clotti...

The anticoagulant rodenticide diphacinone was slightly toxic (acute oral LD50 2014 mg/kg) to Northern bobwhite (Colinus virginianus) in a 14-day acute toxicity trial. Precise and sensitive assays of blood clotting (prothrombin time, Russell's Viper venom time, and thrombin clotting time) were adapted for use in quail, and this combination of assays is recommended to measure the effects of antic...

A membrane lipid abnormality induced by sickling and found as a permanent alteration in the irreversibly sickled cell (ISC) is the rearrangement of phosphatidyl ethanolamine (PE) and phosphatidyl serine (PS) from the inner to the exterior side of the lipid bilayer. Since PS can provide a catalytic surface for the binding of blood coagulation factors and thus can exhibit procoagulant activity, w...

BACKGROUND Hemorrhage and coagulopathy are major contributors to death after trauma. The contribution of red blood cells (RBCs) in correcting coagulopathy is poorly understood. Current methods of measuring coagulopathy may fail to accurately characterize in vivo clotting. We aimed to determine the effect of RBCs on clotting parameters by comparing resuscitation regimens containing RBCs and plas...