The purpose of this study was to investigate whether the anxiolytic effect of cannabidiol (CBD) in humans follows the same pattern of an inverted U-shaped dose-effect curve observed in many animal studies. Sixty healthy subjects of both sexes aged between 18 and 35 years were randomly assigned to five groups that received placebo, clonazepam (1 mg), and CBD (100, 300, and 900 mg). The subjects ...

RATIONALE Early onset epileptic encephalopathy (EOEE) is one of the most serious early onset epilepsies. The etiopathology of this condition remains unclear, and recent evidence indicated that gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 (GABRB3) gene mutations might be associated with EOEE. Furthermore, the therapeutic regimen for EOEE has yet to be well elucidated. Herein, we rep...

pharmaceuticals are considered to be important environmental contaminants. the aim of this study was to evaluate their presence in water intended for public supply to municipally of rio de janeiro, brazil. the regional environmental assessment was done from the analysis of surface water and distribution for the presence of psychiatric drugs. the study reveals the presence of benzodiazepine deri...

This paper describes the development of an electrochemical assay based on screen-printed carbon sensors for the determination of clonazepam in serum and in wine. The cyclic voltammetric behaviour of the drug was investigated and the effects of pH and scan rate on the peak current and peak potential determined. Two reduction peaks were recorded on the initial negative going scan, which were cons...

The withdrawal syndrome from benzodiazepine (BZD) can be severe and in some cases may impede cessation of the use of the drug. We present here a case series of benzodiazepine detoxification by flumazenil infusion, stabilised with clonazepam. Patients were treated with flumazenil 1.35 mg/day for a median of 7 days. Self-reported physical withdrawal symptoms were recorded daily. In addition to fl...

Introduction In recent years, there has been a rise in misuse of low-cost prescription pills across Middle Eastern and North African (MENA) countries. Algeria, Tunisia Morocco, for example, the consumption medications dramatically increased, particularly amongst young marginalized groups. Drugs such as clonazepam pregabalin are extremely popular these regions, they relatively inexpensive percei...

A 50-year-old man was referred for consultation because of disrupted sleep. He complained of a 10-year history of nonrestorative sleep, loud snoring, and a history of “restless leg syndrome.” Ten years previously he developed symptoms of depression. His physician prescribed fluoxetine, a selective serotonin reuptake inhibitor (SSRI) agent. His symptoms of depression improved, however he subsequ...