BACKGROUND This study aims to evaluate the impact of metformin on ovarian response when co-administered during recombinant (r)FSH using the low-dose step-up protocol in clomiphene citrate-resistant polycystic ovarian syndrome (PCOS) patients with normal glucose tolerance. METHODS AND RESULTS Thirty-two patients were randomized to metformin (n = 16) and placebo (n = 16) groups. Hormonal assess...

BACKGROUND Unovulation is the most common cause of infertility. The first line oral treatment has been clomiphene citrate. Another anti-estrogen used for ovulation induction is tamoxifen. Many unovulatory infertile women are resistance to anti-estrogens and need another treatment. Alternative treatments are aromatas inhibitors. OBJECTIVE This study was designed to compare the effectiveness of...

Background: Clomiphene citrate (CC) is still holding its place as the first-line treatment for induction of ovulation in polycystic ovary syndrome (PCOS) patients.  Objective: to assess effect extended clomiphene on pregnancy outcomes resistant PCOS. Patients and methods: this study was conducted 48 PCO patients with CC resistance attended Obstetrics Gynecology Outpatient Clinic at Menoufia U...

Body has defense mechanisms against oxidants in the form of both enzymatic and non enzymatic antioxidants. Oxidants have both physiological and pathological role in female reproduction. Oxidative stress causes damage to the ovaries, oogonia and ovulation as well as in implantation procedures. A study was undertaken to evaluate the polycystic ovary syndrome (PCOS) induced stress in ovarian and u...

OBJECTIVE To evaluate the impact of luteal phase support with vaginal progesterone on pregnancy rates in the intrauterine insemination (IUI) cycles, stimulated with clomiphene citrate and human menopausal gonadotropin (hMG), in sub fertile couples. MATERIALS AND METHODS This prospective, randomized, double blind study was performed in a tertiary infertility center from March 2011 to January 2...

BACKGROUND N-acetyl cysteine (NAC) was proposed as an adjuvant to clomiphene citrate for ovulation induction in patients with polycystic ovary syndrome (PCOS) without clomiphene citrate resistance. OBJECTIVE To evaluate the effect of NAC on pregnancy rate in PCOS patients who were candidates for intrauterine insemination. MATERIALS AND METHODS In this randomized clinical trial, 97 PCOS wome...

A total of 811 intrauterine insemination (IUI) cycles in which clomiphene citrate/human menopausal gonadotrophin (HMG) was used for ovarian stimulation were analysed retrospectively to identify prognostic factors regarding treatment outcome. The overall pregnancy rate was 12.6% per cycle, the multiple pregnancy rate 13.7%, and the miscarriage rate 23.5%. Logistic regression analysis revealed fi...

Seven patients with anorexia nervosa were studied, three during the acute stages of the illness, and four in whom weight gain had been achieved, but who suffered from persistent amenorrhoea of 18 to 79 months' duration.In the acute stage all patients had low serum luteinizing hormone (LH) levels which were unresponsive to clomiphene citrate. In those who had regained weight the mean basal LH le...