normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background : vitiligo is an acquired, autoimmune melanocytic disorder characterized by circumscribed depigmented macules and patches. it affects approximately 0.5-2% of the general population worldwide. many medical treatments have been attempted with partial success, but there has been no previous trial on the combination...

www.thelancet.com Published online March 6, 2017 http://dx.doi.org/10.1016/S0140-6736(17)30549-4 1 Bullous pemphigoid is the most common autoimmune blistering skin disease, and incidence is on the rise, due at least in part to its association with older age. Treatment of bullous pemphigoid presents a challenge to the clinician, as first-line treatment regimens—either oral corticosteroids or who...

Topical corticosteroids have long been the chronic stage in the treatment of steroid responsive dermatitis. Creams containing 0.05% w/w Clobetasol-17-propionate (CP) as active ingredient are categorized as super potent class I topical dermatological corticosteroids. For the drug molecule to reach the cutaneous microcirculation, enhance, the systemic circulation, have to transverse both the lipo...

BACKGROUND Therapy-resistant lichen planus (LP) can be a challenging condition for dermatologists. There are some case reports about successful treatments with alitretinoin of cutaneous and oral, but not of esophageal LP. OBJECTIVE We present the unique case of a patient with cutaneous, oral and esophageal LP which was refractory to classical treatment options (topical clobetasol propionate a...

OBJECTIVE : The purpose of our study was to evaluate whether briefs made of Dermasilk fabric could be an adjuvant tool in the management of vulvar lichen sclerosus (LS). MATERIALS AND METHODS : A controlled, randomized, double-blind study versus placebo was conducted, comparing Dermasilk versus standard cotton briefs in patients affected by LS during treatment with clobetasol propionate 0.05%...

Glucocorticoids are used for the treatment of many diseases, such as inflammatory, allergic, autoimmune, and neoplastic diseases. They can be used in the form of topical, oral, inhalable, rectal, and intra-articular agents. Many topical steroid-related iatrogenic Cushing's syndrome cases affecting especially children have been reported in the literature. Topical steroid-related Cushing's syndro...

The aim of the present study was to investigate the potential of nanoemulsion formulation for topical delivery of Clobetasol propionate (CP) using algal oil (containing omega-3 fatty acids) as the oil phase. CP has anti-inflammatory, immunomodulatory and antiproliferative activities. However, its clinical use is restricted to some extent due to its poor permeability across the skin. Algal oil w...