Healthcare providers are facing an enormous cost pressure and a scarcity of resources, so that they need to realign in the tension between economic efficiency and demand-oriented healthcare. Clinical Practice Guidelines (CPGs) and clinical pathways have been established to improve the quality of care and to reduce costs at the same time. CPGs have a positive impact on the health outcome. Howeve...

Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the canonical Wnt-signaling (or the Wnt/β-Catenin signal transduction) leads to a variety of human diseas...

Clinical pathways are widely adopted by many large hospitals around the world in order to provide high-quality patient treatment and reduce the length of hospital stay of each patient. The development of clinical pathways is a lengthy process, and may require the collaboration among physicians, nurses, and staffs in a hospital. However, the individual differences cause great variances in the ex...

The German health care market is under a rapid rate of change, forcing especially hospitals to provide high-quality services at low costs. Appropriate measures for more effective and efficient service provision are process orientation and decision support by information technology of clinical pathway of a patient. The essential requirements are adequate modelling of clinical pathways as well as...

On first reading, Stephen Bolsin’s editorial presents an encouraging and optimistic view of the way in which medical clinicians see their future roles and responsibilities regarding maintaining standards in Australian health care (Bolsin 2001). Referring to the Bristol case (Bolsin 1999; Hindle 1998), Bolsin says that past lapses provide "unequivocal guidance to doctors in both clinical and man...

PURPOSE Clinical pathways (CPs) are multidisciplinary care plans with essential care steps for patients with specific clinical problems. CPs were introduced in China in 2009 to assure quality, reduce risks, increase resource efficiency and control costs. The purpose of this paper is to present a Chinese public hospital case study where a CP pilot was undertaken to evaluate two main outcomes: le...

OBJECTIVE Clinical pathway analysis, as a pivotal issue in ensuring specialized, standardized, normalized and sophisticated therapy procedures, is receiving increasing attention in the field of medical informatics. Research in clinical pathway analysis has so far mostly focused on looking at aggregated data seen from an external perspective, and only provide very limited insight into the pathwa...

The increase of treatment quality offered by the healthcare organizations is one of the main challenges of the modern health informatics. The personalization of treatment presupposes the real-time adaptation of treatment schemes since the clinical status of the patient and circumstances inside a healthcare organization constantly change. In this paper we present SEMPATH prototype which aims at ...

Background Poor and fragmentary data was available regarding the effects of recombinant-LH (r-LH) in in-vitro granulosa and theca cells of human origin. No data was available from in vivo studies regarding the effects of r-LH supplementation on SCF,EGF,ERK-1/2 and AKT-1 pathways in the follicular fluid of older-poor-responder women undergoing IVF cycle. Evidence from in-vitro and animal studies...