In genetic diagnostics, the emergence of a so-called "patent thicket" is imminent. Such an overlapping set of patent rights may have restrictive effects on further research and development of diagnostic tests, and the provision of clinical diagnostic services. Currently, two models that may facilitate access to and use of patented genetic inventions are attracting much debate in various nationa...

Here we report the adaptation of the CLARITY technique to plant tissues with addition of enzymatic degradation to improve optical clearing and facilitate antibody probe penetration. Plant-Enzyme-Assisted (PEA)-CLARITY, has allowed deep optical visualisation of stains, expressed fluorescent proteins and IgG-antibodies in Tobacco and Arabidopsis leaves. Enzyme treatment enabled penetration of ant...

Understanding the structure-function relationships at cellular, circuit, and organ-wide scale requires 3D anatomical and phenotypical maps, currently unavailable for many organs across species. At the root of this knowledge gap is the absence of a method that enables whole-organ imaging. Herein, we present techniques for tissue clearing in which whole organs and bodies are rendered macromolecul...

Received Dec 20, 2016 Revised May 12, 2017 Accepted Jun 6, 2017 Stability studies of multi machine system are a major concern to power system engineers due to the increasing complexity involved. This paper deals with the application of a nonlinear technique called Dynamic Inversion, to TCSC for the improvement of stability of multi-machine system. The transient stability studies for various cas...

We use the High Current Experiment (HCX) to study three mitigation measures: a rough surface to reduce electron emission and gas desorption from ions striking walls near grazing incidence, a suppressor electrode after the magnets to block beam-induced electrons off the end structures from drifting upstream, and clearing electrodes to remove electrons from drift regions between magnets. We find ...

The problem of market clearing in an economy is that of finding prices such that supply meets demand. In this work, we propose a kernel method to compute nonlinear clearing prices for instances where linear prices do not suffice. We first present a procedure that, given a sample of values and costs for a set of bundles, implicitly computes nonlinear clearing prices by solving an appropriately f...