Clinical studies have demonstrated an altered pineal function in cancer patients. Owing to the documented antineoplastic activity of the pineal gland, these anomalies could have a prognostic significance. This study was carried out to monitor the effect of higher blood levels of melatonin, the most important pineal hormone, which could be applied in relation to the response to chemotherapy in h...

human embryonic stem cells (hESCs) are able to differentiate in all different specialized tissues [1]. Yet, as all living cells, they have to cope with endogenous or exogenous DNA damage. Their efficacy in DNA repair is somewhat controversial. Clearly hESCs can achieve the indispensable genome stability either by more effective repair or, on the contrary, by increasing apoptosis thus eliminatin...

Cadmium, is a highly toxic heavy metal, and is a known carcinogen, clastogen and a mutagen and it poses severe risk to human health. Humans are exposed to cadmium via variable modes i.e. through food and drinking water, by inhalation, cigarette smoking etc. It serves no physiological function within mammalian system. ATSDR (The Agency for Toxic Substances and Disease Registry) has listed cadmiu...

W syndrome (WS) is an autosomal recessive disease, which is characterized by premature aging, short stature, cataract, dermal atrophy and ulcers, turning white early on hairs, alopecia, vascular calcification, diabetes mellitus, and osteoporosis.1,2 Kidney involvement is rarely seen in WS.3,4 We report a case of WS associated with end stage renal failure without any risk factor. A 29-year-old m...

Background: The effects in health of food containing phenolic compounds require currently studies related to safety. It has been established that these compounds may exhibit dual activity (antioxidant/pro-oxidant effects). Aims: The current work is focused on an in silico study to determine the relationships between different thermodynamic parameters and genotoxicity (GT) of phenolic compounds,...