BACKGROUND The most common cause of physical disability in children is cerebral palsy. This study was aimed to evaluate the effect of citicoline in combination to physiotherapy versus physiotherapy alone, to improve the functional outcome in pediatric cerebral palsy. METHODS The clinical trial was performed on 50 pediatric patients aged 18-75 months with spastic diplegia or quadriplegic cereb...

Introduction : This study was designed to evaluate the effect activity of RAIL-gel in comparison with Citicoline on nitroxydergic system during acute cerebrovascular accident. Methods In this study, 80 white nonlinear rats were randomly assigned 4 groups (20 each): 1) intact; 2) control - untreated accident (ACVA), examined th day; 3) animals ACVA, receiving RAIL, 18 4) treated Citicoline, day....

Introduction: Amblyopia significantly contributes to low vision and blindness in adults an Indonesian rural setting. The treatment of amblyopia, particularly anisometropic and/or strabismic has long been challenging for many clinicians. This study aims report a promising result refractive correction, occlusion therapy, oral citicoline on mixed amblyopia with optic nerve hypoplasia adult patient...

Citicoline is able to inhibit apoptosis associated with cerebral isch emia and several models of neurodegeneration [1–3]. It can also potentiate neuroplasticity and is a natural precursor of phosphatidylcholine, one of the most important structural phospholipids in the neuronal membranes. Furthermore, since it is formed by choline, it works for biosynthesis of acetylcholine [1–3], CDP-choline i...