These are the notes of my talk presented in the colloquium on discrete curvature at the CIRM, in Luminy (France) on November 21st, 2013, in which we study the space of triangulations from a purely geometric point of view and revisit the results presented in [21] and [20] (joint works with Patrick Mullen, Fernando De Goes and Mathieu Desbrun). Motivated by practical numerical issues in a number ...

T he recent action by the Obama administration to overturn restrictions on federal funding for embryonic stem cell research is expected to breathe new life into the field. The change in policy, which was made offi cial on March 9, lifted the ban on the use of federal funds for any research involving human embryonic stem cell lines established after August 9, 2001, when then-President George W. ...

As an example of the burgeoning importance of stem cell therapy, this past month the California Institute for Regenerative Medicine (CIRM) has approved $70 million to create a new network of stem cell clinical trial centers. Much work in the last decade has been devoted to developing the use of autologous and allogeneic adult stem cell transplants to treat a number of conditions, including hear...

Free fatty acids are important flavor compounds in cheese. Propionibacterium freudenreichii is the main agent of their release through lipolysis in Swiss cheese. Our aim was to identify the esterase(s) involved in lipolysis by P. freudenreichii. We targeted two previously identified esterases: one secreted esterase, PF#279, and one putative cell wall-anchored esterase, PF#774. To evaluate their...

May 2006 | Volume 3 | Issue 5 | e126 In November 2004, California voters approved a ten-year, US$3 billion stem cell research program to pursue cures for diabetes, Parkinson disease, spinal cord injuries, and other chronic conditions. Campaign organizers also claimed the state would receive royalties from new therapies, economic development in the form of jobs and taxes, and access to cheaper m...

Effective immunotherapy options are lacking for patients with advanced NSCLC who progress on a PD-(L)1 inhibitor and those that EGFR or ALK positive after progression TKI therapy. One potential approach to improve ICI efficacy is promote cytolytic T cell infiltration into tumors. This can be accomplished via in situ vaccination functional antigen presenting cells which take advantage of the ful...

AIMS Propionibacterium freudenreichii is an actinobacterium widely used in dairy industry during the ripening process of Swiss-type cheeses and which presents probiotic properties. P. freudenreichii is reportedly a hardy bacterium, able to survive during the cheese-making process and when subjected to digestive stresses. During this study the long-term survival (LTS) of P. freudenreichii was in...

This text is an extension of lectures notes I prepared for les Journées Nationales de Calcul Formel held at the CIRM, Luminy (France) on May 3-7, 2010. The main purpose of these lectures was to introduce the French community of symbolic computation to the constructive approach to algebraic analysis and particularly to algebraic D-modules, its applications to mathematical systems theory and its ...

These are notes for a lecture given at CIRM in 2014, for the Journées Nationales du Calcul Formel . We explain the basic algorithms based on combining congruences for solving the integer factorization and the discrete logarithm problems. We highlight two particular situations where the interaction with symbolic computation is visible: the use of Gröbner basis in Joux's algorithm for discrete lo...