A man with acute myelogenous leukemia, treated with chemotherapy, had a decrease in circulating formed blood elements. Bone marrow biopsy revealed necrosis. Imaging with In-Ill chloride demonstrated activity in the liver, but not in the spleen or bone marrow. Eighteen days later, the circulating blood count had risen; a repeat bone marrow biopsy showed the return of blood cell precursors....

BACKGROUND/AIM Carcinomas of unknown primary origin (CUPs) account for 3%-5% of all malignancies. The majority of CUPs have unfavorable prognosis and are chemoresistant. Predictive biomarkers should be established to improve therapeutic outcomes. Metastatic ability of CUPs may be related to the existence of circulating tumor cells (CTCs). PATIENTS AND METHODS Ten patients diagnosed with CUP v...

DNA is generally considered to be chemically rather inert, but self-cleaving DNA molecules have recently been isolated from in vitro selection experiments; their properties advance the idea that, like RNA, DNA can serve as both a catalyst and an information storage medium.

We study the effect of homogenization on flame propagation in periodic excitable media, when the width of the flame is much smaller than the characteristic size of the heterogeneities.

Note: Ten chapters were prepared as background for the work of the Maize Advisory Group and for input to the public symposium, held 11 March 2004, in Oaxaca as part of the CEC Article 13 study on maize and biodiversity. These chapters were later reviewed and revised prior to this release, based on comments received at the symposium and during the subsequent comment period. Responses to reviewer...

Circulating (CTCs) and disseminated tumor cells (DTCs) are two different steps in the metastatic process. Several recent techniques have allowed detection of these cells in patients, and have generated many results using different isolation techniques in small cohorts. Herein, we review the detection results and their clinical consequence in esophageal, gastric, pancreatic, colorectal, and live...

MicroRNAs have been found to be deregulated in several diseases and, due to their high stability in body fluids, represent promising noninvasively detectable biomarkers. However, numerous technical variables can affect accurate measurement of circulating miRNAs. Using a microarray-based method we assessed the: (i) adequate intra- and inter-array reproducibility of miRNA profiling; (ii) feasibil...