This study was undertaken to develop a novel anti-citrullinated peptide antibody (ACPA) and to investigate its arthritogenicity in a collagen-induced arthritis (CIA) model. The novel ACPA, 12G1, was developed by injecting cyclic citrullinated antigen in mice and subsequently hybridizing the B cells producing citrullinated peptide-specific antibodies with a myeloma cell line. The arthritic joint...

by Aileen Lavin A subcommittee of the Academic Committee chaired by David T. Link, dean of the Law School, is evaluating proposed guidelines to regulate relations between the University and the CIA. The subcommittee is still in its very early stages, but plans to complete its research and have guidelines in effect by the fall sem ester. Although Notre Dame has never had specific rules concernin...

BACKGROUND IL-4 is a cytokine that induces differentiation of naive helper T cells into Th2 cells. Once activated by IL-4, Th2 cells subsequently produce additional IL-4. OBJECTIVE To examine the effect of IL-4 on IL-17 production and its effect in Collagen-Induced Arthritis (CIA) mice. METHOD In this study, a chicken collagen-II-induced experimental arthritis (CIA) model was used in DBA/1 ...

The present work investigates the Collision Induced Absorption (CIA) bands of oxygen that occur at 1065 and 1270 nm from solar occultation data obtained with the spaceborne spectrometer SCIAMACHY. The effort is motivated by the interest in these two strong CIA bands in atmospheric research and the paucity of data on them under realistic atmospheric conditions. The observing geometry provides lo...

Objective. To explore the bidirectional relationship between the development of rheumatoid arthritis and atherosclerosis using bovine collagen type II (col II) immunized B10.RIII.ApoE mice, a murine model of spontaneous atherosclerosis and collagen-induced arthritis (CIA). Methods. B10.RIII.ApoE male mice and wild type controls were immunized with 150 g of col II emulsified in complete Freund’...

Background: Chemotherapy-induced alopecia (CIA) is a common side effect of cancer treatment with profound psychosocial repercussions. Several young (before day 14) and adult (after 3 weeks) murine models for CIA have been developed, yet no study thus far has compared these models. Young models are naturally synchronized in anagen while adult models require synchronization into anagen. Here, we ...

Type II collagen-induced arthritis (CIA) is an experimentally inducible autoimmune disorder that is, just like several forms of human arthritis, influenced by a genetic background. Immunization of young rhesus monkeys (Macaca mulatta) with type II collagen (CII) induced CIA in about 70% of the animals. One major histocompatibility complex (MHC) class I allele was present only in young animals r...

This study focused on the potential therapeutic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on collagen-induced arthritis (CIA) and on the elucidation of the mechanisms involved. DBA/1J mice with established CIA were treated with various amount of recombinant soluble human TRAIL. The effects of TRAIL on the development and severity of CIA in this DBA/1J mouse model...

INTRODUCTION Statins (hydroxymethylglutaryl coenzyme A reductase inhibitors) are effective in reducing the risk of cardiovascular morbidity and mortality in patients with hyperlipidemia, hypertension, or type II diabetes. Next to their cholesterol-lowering activity, statins have immunomodulatory properties. Based on these properties, we hypothesized that statin use may eventually lead to dysreg...