OBJECTIVE This in vivo (1)H magnetic resonance spectroscopy study examined levels of glutamate, glutamine, and N-acetylaspartate in medicated patients with chronic schizophrenia. METHOD Localized in vivo (1)H spectra were acquired at 4.0 T from the left anterior cingulate and thalamus of 21 patients with schizophrenia and 21 comparable healthy volunteers. RESULTS Significantly lower levels ...

BACKGROUND There is little information on lung function and respiratory diseases in people with psychosis. AIMS To compare the respiratory health of people with psychosis with that of the general population. METHOD In a nationally representative sample of 8028 adult Finns, lung function was measured by spirometry. Information on respiratory diseases and symptoms was collected. Smoking was q...

objective: the current study was performed to evaluate the cognitive improvements of the chronic schizophrenic patients treated with risperidone in comparison with those treated with haloperidol according to wisconsin card sorting test (wcst). methods: in a double blind clinical trial, 65 patients with a diagnosis of chronic schizophrenia were randomly allocated into two groups. they received a...

BACKGROUND Treatment of negative symptoms in chronic schizophrenia continues to be a major clinical issue. AIMS To analyse the efficacy of add-on antidepressants for the treatment of negative symptoms of chronic schizophrenia. METHOD Systematic review and meta-analysis of randomised controlled trials comparing the effect of antidepressants and placebo on the negative symptoms of chronic sch...

The average life expectancy of people living with schizophrenia is about 10 to 20 years less than that of the general population and research has shown quite conclusively that people with schizophrenia have increased rates of physical illnesses; in fact over 75% of people with a diagnosis of schizophrenia have at least one chronic physical condition running alongside their schizophrenia and the...

The average life expectancy of people living with schizophrenia is about 10 to 20 years less than that of the general population and research has shown quite conclusively that people with schizophrenia have increased rates of physical illnesses; in fact over 75% of people with a diagnosis of schizophrenia have at least one chronic physical condition running alongside their schizophrenia and the...

OBJECTIVE The present study reviewed voxel-based morphometry (VBM) studies on high-risk individuals with schizophrenia, patients experiencing their first-episode schizophrenia (FES), and those with chronic schizophrenia. We predicted that gray matter abnormalities would show progressive changes, with most extensive abnormalities in the chronic group relative to FES and least in the high-risk gr...

INTRODUCTION Chronic medicated patients with schizophrenia have marked reductions in sleep spindle activity and a correlated deficit in sleep-dependent memory consolidation. Using archival data, we investigated whether antipsychotic-naïve early course patients with schizophrenia and young non-psychotic first-degree relatives of patients with schizophrenia also show reduced sleep spindle activit...